Animal: Bovine or ovine respiratory diseases (BRD) caused by Mannheimia (Pasturella) haemolytica.Poultry: Pasteurellosis, mycoplasmosis, CRD, CCRD
Tilmicosin inhibits bacterial protein synthesis by binding to 50S ribosome.
Cattle, sheep: by subcutaneous, 10 mg/kg, Pig: Pneumonia: 181-383 gm/ton of feed;Poultry: by addition to drinking water, 75 mg/Litre.
Do not administer to any animals IV or death can result. Do not administer to goats. It is not recommended for small animals. Tilmicosin has been shown to be fatal in swine (when injected), non-human primates and potentially, in horses. Tilmicosin reaches high concentrations in milk for up to 42 days. Do not administer to lactating dairy cattle. Avoid direct contact with eyes. Accidental self-injection can be fatal in humans. Fatal cardiac reactions caused by injections have been reported in people. Accidental injection in people requires immediate treatment. Emergency treatment includes applying ice to injection site. Do not use in automatically powered syringes
IM injections may cause a local tissue reaction resulting in trim loss. Edema is possible at SC injection site. Tilmicosin may be cardiotoxic in some animals. Injections to pigs have been fatal because of cardiotoxicity. The cardiac effects are increased heart rate and decreased contractility. Rabbit: Weakness, pallor, tachypnea and sudden death. May cause acute death if given IV. SC injections can cause local swelling and necrosis
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