Tilmicosin is a semi-synthetic macrolide antibiotic; a basic, lipid-soluble compound consisting of a lactone ring to which is attached deoxy sugar. The commercial products are found as Tilmicosin phosphate. The spectrum of activity is limited primarily to gram-positive aerobic bacteria; Mycoplasma; and respiratory pathogens such as Pasteurella multocida, Mannheimia haemolytica, and Histophilus somni. Tilmicosin administered to calves (15 mg/kg SC) reduced expression of prostaglandin (PGE2) stimulated by bacteria. There also may be some anti-inflammatory effects such as reduced leukocyte release of inflammatory mediators in the lungs. There also may be reduced prostaglandin synthesis with tilmicosin administration in alveolar macrophages.
Animal: Bovine or ovine respiratory diseases (BRD) caused by Mannheimia (Pasturella) haemolytica.Poultry: Pasteurellosis, mycoplasmosis, CRD, CCRD
Tilmicosin inhibits bacterial protein synthesis by binding to 50S ribosome.
Cattle, sheep: by subcutaneous, 10 mg/kg, Pig: Pneumonia: 181-383 gm/ton of feed;Poultry: by addition to drinking water, 75 mg/Litre.
Should not be taken at the same time with tetracycline because it interferes with the absorption & effectiveness of this medication.
Do not administer to any animals IV or death can result. Do not administer to goats. It is not recommended for small animals. Tilmicosin has been shown to be fatal in swine (when injected), non-human primates and potentially, in horses. Tilmicosin reaches high concentrations in milk for up to 42 days. Do not administer to lactating dairy cattle. Avoid direct contact with eyes. Accidental self-injection can be fatal in humans. Fatal cardiac reactions caused by injections have been reported in people. Accidental injection in people requires immediate treatment. Emergency treatment includes applying ice to injection site. Do not use in automatically powered syringes
IM injections may cause a local tissue reaction resulting in trim loss. Edema is possible at SC injection site. Tilmicosin may be cardiotoxic in some animals. Injections to pigs have been fatal because of cardiotoxicity. The cardiac effects are increased heart rate and decreased contractility. Rabbit: Weakness, pallor, tachypnea and sudden death. May cause acute death if given IV. SC injections can cause local swelling and necrosis
Cattle: Meat- 28 days, Milk- Nil. Poultry: Broiler- 12 days, Turkey- 19 days.
Store below 25° C, protect from light. Keep out of the reach of the children.
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