Cinnarizine is predominantly used to treat nausea and vomiting associated with motion sickness, vertigo, Ménière's disease, or Cogan's syndrome. In fact, it is one of only a select few drugs that has shown a beneficial effect in the chronic treatment of the vertigo and tinnitus, associated with Meniere's disease.
Calcium-channel blocker; Antiemetic
This contains two active ingredients Cinnarizine and Dimenhydrinate. The two substances belong to different groups of medicines. Cinnarizine is part of a group called calcium antagonists. Dimenhydrinate belongs to a group called antihistamines. Both substances work by reducing symptoms of vertigo (a feeling of dizziness or spinning) and nausea (feeling sick). The combination product is more effective than the individual compounds.
ORAL Motion sickness: Adult: 30 mg taken 2 hr before travel & 15 mg every 8 hr during the journey if necessary. Child: 5-12 yr: 1/2 of adult dose. Vertigo & vestibular disorders: Adult: 30 mg tid. Child: 5-12 yr:1/2of adult dose.
Concurrent use of alcohol, CNS depressants or tricyclic antidepressants may potentiate the sedative effects of either these drugs or of Cinnarizine and Dimenhydrinate. Therefore, it is advisable to avoid these drugs while taking Cinnarizine and Dimenhydrinate.
Proven hypersensitivity to the drug. Parkinson’s disease. Childn & neonates. Hypotension; pregnancy; lactation; elderly. May impair ability to drive or operate machineries.
Extrapyramidal symptoms sometimes associated w/ severe depression. Drowsiness, headache, GI upsets, unsteadiness, headache; rarely skin & hypersensitivity reactions, dry mouth, blurred vision, urinary difficulty or retention, constipation & increased gastric reflux, fatigue. Hypollpidaemic effect.
During pregnancy and lactation (breastfeeding) Cinnarizine Quality Pharmaceutical Laboratory usage is possible only in exceptional cases, when the expected benefit to the mother far outweighs the potential risk to the fetus or infant.
Drowsiness, dizziness and ataxia with anticholinergic effects such as dry mouth, flushing of the face, dilated pupils, tachycardia, pyrexia, headache and urinary retention. General supportive measures should be used to treat respiratory insufficiency or circulatory failure. Gastric lavage with isotonic sodium chloride solution is recommended.
Store in a cool (below 30°C) and dry place. Keep away from light and out of reach of children.
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