Zolibac

Susceptible bacterial infections including septicemia, respiratory, biliary or GU tract, skin and skin structure, bone and joint, endocarditis. Surgical prophylaxis

Antibiotic

Cefazolin is a 1st generation broad spectrum parenteral Cephalosporin antibiotic.It interferes with the synthesis of bacterial cell wall by inhibiting transpeptidase enzyme. As a result the bacterial cell wall is weakened,the cell swells and then ruptures.

Adult: Pneumococcal pneumonia: 500mg every 12 hours. Mild infections: 250?500mg every 8 hours; moderate to severe infections: 500mg?1g every 6?8 hours. Severe, life-threatening infections (eg, endocarditis, septicemia): 1?1.5g every 6 hours; max 12g/day. UTIs: 1g every 12 hours. Prophylaxis: see literature. Renal impairment (give initial loading dose): (CrCl 35?54mL/min): reduce dosing frequency to at least 8 hour intervals; (CrCl 11?34mL/min): reduce dose by 50%, give every 12 hours; (CrCl <10mL/min): reduce dose by 50%, give every 18?24 hours. Children: <1 month: not recommended. ?1 month: Mild to moderately severe infections: 25?50mg/kg per day in 3?4 divided doses. Severe infections: max 100mg/kg per day. Renal impairment (give initial loading dose): (CrCl 40?70mL/min): reduce dose by 40%; give every 12 hours; (CrCl 20?40mL/min): reduce dose by 75%, give every 12 hours; (CrCl 5?20mL/min): reduce dose by 90%, give every 24 hours.

Probenecid may decrease renal tubular secretion of Cephalosporins when used concurrently, resulting in increased and more prolonged Cephalosporin blood levels.

Penicillin or other allergy. Renal impairment: reduce dose. GI disease (esp. colitis). Monitor PT in patients at risk (eg, renal or hepatic impairment, poor nutritional state, long term use, or anticoagulant therapy). Pregnancy (Cat.B). Nursing mothers.

Anorexia, Diarrhea, Eosinophilia, Fever, Increased transaminases, Leukopenia, Nausea and vomiting, Neutropenia, Oral candidiasis, Pain at injection site, Phlebitis, Pseudomembranous colitis, Seizure, Stevens-Johnson syndrome, Thrombocytopenia, Thrombocytosis, Transient elevation of hepatic enzymes, Vaginitis

Cefazolin is pregnancy category B, indicating general safety for use in pregnancy. Caution should be used in breastfeeding as a small amount of cefazolin enters the breast milk. Cefazolin can be used prophylactically against perinatal Group B streptococcal infection (GBS)

After reconstitution, Cefazolin is stable for 24 hours at room temperature or for 10 days if stored under refrigeration (5°C). Reconstituted solution may range in color from pale yellow to yellow without a change in potency.