This medication is used for temporary relief of congestion in the nose caused by various conditions including the common cold, sinusitis, hay fever, and allergies. It works by narrowing the blood vessels in the nose area, reducing swelling and congestion.
Sympathomimetic Decongestant
Xylometazoline Hydrochloride is a sympathomimetic agent with alpha-adrenergic activity. It produces vasoconstriction thus reducing nasal congestion. This enables patients suffering from colds to breathe more easily through the nose.
Sodium Cromoglicate usually acts through a local effect on the nasal mucosa. It prevents release of the mediators of type-l allergic reactions, including histamine and slow reacting substance of anaphylaxis (SRS-A) from sensitized mast cells after the antigen-antibody union has taken place. The drug does not inhibit the binding of IgE and the specific antigen; instead it suppresses the release of substances (e.g., histamine, SRS-A) in response to this reaction. The drug also inhibits Type-III (late allergic, Arthers) reactions to a lesser extent.
NASAL Nasal congestion: Adult:As 0.1% solution: Instill into each nostril bid-tid. Max duration: 7 days. Child:As 0.05% solution: 3 mth-12 yr: 1-2 drops into each nostril once or bid. Max duration: 7 days.
Angle closure glaucoma; dry rhinitis; post trans-sphenoidal hypophysectomy, transnasal, trans-oral surgery where dura mater is exposed. Young children, pregnancy & lactation. Hypertension, CV abnormalities, DM. hyperthyroidism, history of excessive reaction to sympathomimetics, difficulty in urination secondary to prostate enlargement. Rebound congestion may occur after prolonged regular use.
Headache, insomnia, tachycardia, hypertension, nervousness, nausea, dizziness, palpitation, arrhythmia. Nasal drops: Local stinging or burning, sneezing, dryness of mouth & throat, nausea. Eye drops: Dryness of eye.
Pregnancy— Adequate and well-controlled studies in humans have not been done. It is not known whether xylometazoline is distributed into breast milk. However, problems in humans have not been documented.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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