Ivermectin & Clorsulon acts against gastrointestinal roundworms (adult and fourth stage larvae) • Oesophagostomumradiatum • Ostertagiaostertagi • Haemonchusplacei • Trichostrongylusaxei, • Cooperiaoncophora • C. punctata • C. pectinata • Bunostomumphlebotomum Lungworms (adult and fourth stage larvae) Dictyocaulus viviparous Cattle grubs (Parasitic developmental stages) • Hypodermabovis • Hypodermalineatum Sucking Lice • Linognathusvituli, • Haematopinuseurysternus • Solenopotescapillatus Mange mites (scabies) • Psoroptesovis • Sarcoptesscabiei var. bovis. Liver Flukes • Fasciola (adults only)
Ivermectin have strong affinity to glutamate gated chloride ion channel of nerves and causes hyper-polarization of the nerve or muscles cells and resulting paralysis and killing of parasites. Clorsulon is rapidly absorbed into the circulating blood. Erythrocytes with bound drug as well as plasma are ingested by Fasciola. Adult Fasciola are killed by clorsulon because of inhibition of enzymes in the glycolytic pathway, which is their primary source of energy. Ivermectin is metabolized in the liver and its metabolites are excreted almost exclusively in the feces over an estimated 12 days with less than 1% of the administered dose excreted in the urine.
Ivermectin and Clorsuloncan be administered Sub-cutaneous (SC) route as follows: Cattle/Buffalo/Sheep/Goat: 1ml/50kg body weight (200mcg/kg body weight and Clorsulon 2mg/kg body weight)
Animal with history of hypersensitivity is contraindicated to use of Ivermectin&Clorsulon.
Animal may show unusual movement of the body immediately after injection of Ivermectin&Clorsulon injection and recovered within few minutes. At the site subcutaneous injectionswelling of the loose tissue occurs and recuperates without further treatment.
During pregnancy and lactation use of Ivermectin and Clorsulon at recommended dose is safe.
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