For control of severe nausea & vomiting caused by radiation therapy, cancer chemotherapy, surgery, & other conditions. Relieving nausea, vomiting & attacks of dizziness or spinning sensations (vertigo) associated with Meniere’s disease & other inner ear disorders, for the treatment Psychotic illness such as schizophrenia (hallucinations & hostility), acute mania, for the short-term treatment of generalized non-psychotic anxiety.
Phenothia.zine; Antiemetic
Prochlorperazine is a dopamine & histamine antagonist. The mechanism of antiemetic activity is due to the blockade of histamine H, & dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. It also has a weak anticholinergic effect and prevents acid reflux by increasing the tone of the lower oesophageal sphincter.
Children (not recommended in children <10 kg or <2 years): 10-14 kg: 2.5 mg every 12-24 hours as needed; maximum: 7.5 mg/day 15-18 kg: 2.5 mg every 8-12 hours as needed; maximum: 10 mg/day 19-39 kg: 5 mg every 12 hours as needed; maximum: 15 mg/day Adults: Oral: 5-10 mg 3-4 times/day; usual maximum: 40 mg/day
Alcohol, barbiturate & other sedatives may increase the CNS depressant action. Some drugs like Antacids, antiparkinson's drug, lithium may interfere the absorption of Prochlorperazine. This drug may interfere with the plasma concentration of Propanolol and Phenobarbital.
Hypersensitivity to prochlorperazine or any component of the formulation, severe CNS depression; coma; should not be used in children <2 years of age or <10 kg. Very high or very low blood pressure, liver or heart disease, Reye’s syndrome, alcohol or drug dependencies, nervous system problems, blood disorders, allergies (especially drug allergies). Caution should be taken while performing tasks that require alertness, such as driving or using machinery. Use of alcohol can cause extreme drowsiness. This medication may increase sensitivity to sunlight. Prolonged sun exposure should be avoided & a sunscreen & protective clothing should be taken when anybody is exposed to the sun. This medication can reduce sweating making more susceptible to heat stroke.
Drowsiness, jaw, neck, & back muscle spasms, fine worm-like tongue movements, rhythmic face, mouth, or jaw movements, slow or difficult speech, difficulty swallowing, restlessness & pacing, tremors, shuffling walk, skin rash, yellowing of the skin or eyes.
No evidence of adverse Effects of this drug has been reported during pregnancy & lactation.
Symptoms of overdose include deep sleep, coma, extrapyramidal symptoms, abnormal involuntary muscle movements, and hypotension.
Store below 30°C.Protect from light and moisture. Keep out of the reach of children.
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