It is a vesicular monoamine transporter 2 (VMAT) inhibitor indicated for the treatment of chorea associated with Huntington’s disease
Atypical neuroleptic drugs
Tetrabenazine is a drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders, It is a vesicular monoamine transporter-2 (VMAT-2) inhibitor that used as symptomatic treatment of chorea associated with Huntington's disease.
Individualization of dose with careful weekly titration is required. The 1st week’s starting dose is 12.5 mg daily; 2nd week,25 mg (12.5 mg twice daily); then slowly titrate at weekly intervals by 12.5 mg to a tolerated dose that reduces chorea. ? Doses of 37.5 mg and up to 50 mg per day should be administered in three divided doses per day with a maximum recommended single dose not to exceed 25 mg. ? Patients requiring doses above 50 mg per day should be genotyped for the drug metabolizing enzyme CYP2D6 to determine if the patient is a poor metabolizer (PM) or an extensive metabolizer (EM). ? Maximum daily dose in PMs: 50 mg with a maximum single dose of 25 mg
With medicine: Strong CYP2D6 Inhibitors: A reduction in Tetrabenazine dose may be necessary when adding a strong CYP2D6 inhibitor (e.g., fluoxetine, paroxetine, quinidine) in patients maintained on a stable dose of Tetrabenazine.
Reserpine: Reserpine binds irreversibly to VMAT2, and the duration of its effect is several days. At least 20 days should elapse after stopping reserpine before starting Tetrabenazine, Tetrabenazine and Reserpine should not be used concomitantly.
With food & others: No interaction with food, can be taken with or without food.
Actively suicidal,or who have depression which is untreated or undertreated ? Hepatic impairment ? Taking monoamine oxidase inhibitors (MAOIs) or reserpine ? Taking deutetrabenazine or valbenazine
Sedation/somnolence,fatigue,insomnia,depression,akathisia, anxiety/anxiety aggravated,nausea.
Pregnancy: Based on animal data,may cause fetal harm,Breast feeding: Abiraterone is not for use in women. It is not known if either abiraterone acetate or its metabolites are excreted in human milk
Signs and symptoms of overdosage of Tetrabenazine may include drowsiness, sweating and hypothermia.
Store in a cool & dry place. protect from light & moisture. Keep all medicines out of the reach of the children.
.png&w=384&q=75)