Osteoporosis in postmenopausal women, osteoporosis in men, osteoporosis in men & women that is caused by treatment with steroid medicines such as prednisone, Paget$#$#$#$s disease of bone in men & women.
Your body is constantly breaking down old bone and making new bone tissue. If you have osteoporosis, your body breaks down more bone than it forms so gradually bone loss occurs and your bones become thinner and fragile. This is especially common in women after menopause (change of life). Many people with osteoporosis have no symptoms and you may not even know that you have it. However, osteoporosis makes you more likely to have fractures (break bones), especially in your spine, hips and wrists.
Risedronate has an affinity for hydroxyapatite crystals in bone and acts as an antiresorptive agent. At the cellular level, Risedronat inhibits osteoclasts. The osteoclasts adhere normally to the bone surface but show evidence of reduced active resorption.
One tablet orally, taken once a month. To permit adequate absorption, tablet must be taken at least 30 minutes before the first food, beverage or medication of the day with plain water only.
Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription specially aspirin or other NSAIDs. Antacids, supplements, or medicines that contain aluminum, calcium, magnesium, or other minerals can interfere with how your body absorbs Risedronate Sodium. If you use these other medicines, do not take them for at least 30 minutes after taking a Risedronate Sodium tablet.
Risedronate may cause upper gastrointestinal disorders such as dysphagia, esophagitis, & esophageal or gastric ulcers. It should be taken according to the dosing instructions to minimize the risk of these events. Patients should discontinue use if new or worsening symptoms occur. Calcium supplement, antacids & some oral medications will interfere with absorption of Risedronate if taken at the same time. Intravenous ranitidine makes the bioavailability of oral Risedronate double. Incidence of upper gastro-intestinal adverse events associated with NSAID & aspirin appears to be greater with concomitant administration of Alendronate.
Usually mild & generally do not require discontinuation of therapy. Side Effects include esophagus or stomach problems, including ulcers, pain, or trouble swallowing, low calcium & other mineral disturbances, pain in bones, joints or muscles, sometimes severe, jaw-bone problems in some people, which may include infection & slower healing after teeth are pulled & short-lasting, mild flu-like symptoms, & usually get better after the first dose.
Pregnancy Category C. It is only intended for use in postmenopausal women. It is not known whether Risedronate is excreted in human milk. It should not be given to nursing women.
No specific information is available on the treatment of overdose with Risedronate Sodium. Decreases in serum calcium following substantial overdose may be expected. Signs and symptoms of hypocalcaemia may also occur in some of these patients. Milk or antacids containing magnesium, calcium or aluminium should be given to bind Risedronate and reduce absorption of Risedronate Sodium. In cases of substantial overdose, gastric lavage may be considered to remove unabsorbed Risedronate Sodium.
Store in a cool and dry place. Protect from light & moisture. Keep out of the reach of children.
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