Peranel

Perampanel is a non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy.

non-competitive AMPA glutamate receptor

Noncompetitive antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons; glutamate is a primary excitatory neurotransmitter in the CNS and is implicated in various neurological disorders caused by neuronal over excitation

The mechanism for its antiepileptic effects in humans is still unknown

In absence of concomitant enzyme-inducing antiepileptic drugs (AEDs): 2 mg PO qHS initially; increase by 2 mg/day increments in at least weekly intervals based on clinical response and tolerability to 4-8 mg qHS

Contraceptives: 12 mg once daily may decrease the effectiveness of hormonal contraceptives containing levonorgestrel. Moderate and Strong CYP3A4 Inducers (including carbamazepine, oxcarbazepine, and phenytoin): increase the clearance of Peranel and decrease Peranel plasma concentrations.

Precautions & Warnings Suicidal Behavior and Ideation: Monitor for suicidal thoughts or Behaviour. Neurologic Effects: Monitor for dizziness, gait disturbance, somnolence and fatigue. Falls: Monitor for falls and injuries. Drug Reaction with Eosinophilia and Systemic Symptoms/Multi-organ Hypersensitivity: Discontinue if no alternate etiology. Withdrawal of Antiepileptic Drugs: In patients with epilepsy, there may be an increase in seizure frequency.

Peranel may cause Serious Psychiatric and Behavioral Reactions, Suicidal Behavior and Ideation, Dizziness, Somnolence, Fatigue, Irritability, Falls, Nausea, Ataxia, Balance Disorder etc.

There are no adequate data on the developmental risk associated with use in pregnant women; in animal studies, perampanel induced developmental toxicity in pregnant rat and rabbit at clinically relevant doses

Store at room temperature: 68 - 77°F (20- 25°C); excursions permitted to 59-86°F (15-30°C)

Safe