For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia.
Benzylpenicillin & Phenoxymethyl penicillin
Adult: Oral: Susceptible infections: 125-312 mg 4-6 hrly. IM/IV: Susceptible infections: 0.6-3.6 g/day in 4-6 divided doses. IV: Bacterial endocarditis: 7.2-12 g/day in divided doses. Intrapartum prophylaxis against group B Streptoccocal infection in neonates Initial: 3 g, followed by 1.5 g 4 hrly until delivery. Meningococcal meningitis; Pneumococcal meningitis: 2.4 g 4 hrly. Max: 18 g/day in meningococcal meningitis. Child: IV: Meningococcal meningitis, Pneumococcal meningitis: Newborn infants: 100 mg/kg daily in 2 divided doses; 1-4 wk: 150 mg/kg daily in 3 divided doses; >1 mth to 12 yr: 180-300 mg/kg daily in 4-6 divided doses. Parenteral: susceptible infections: Newborn infants: 50 mg/kg daily in 2 divided doses; 1-4 wk: 75 mg/kg daily in 3 divided doses; >1 mth to 12 yr: 100 mg/kg daily in divided doses, not exceeding 4 g/day.
Hypersensitivity to benzylpenicillin and other penicillins. Patient with history of allergy esp ?-lactam allergy and/or asthma, seizure disorder. Diabetic patients. Renal impairment. Pregnancy and lactation.
Nausea, vomiting, stomatitis, black or hairy tongue, rash, fever, serum-like sickness, convulsions, interstitial nephritis, haemolytic anaemia, granulocytopenia, agranulocytosis, leucopenia, thrombocytopenia.
Pregnancy category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1st trimester. Lactation: Monitor electrolyte, hepatic, renal, cardiac and haematologic function; signs and symptoms of anaphylaxis during 1st dose.
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