Indicated for the treatment of - Benign gastric ulcer, duodenal ulcer, gastroesophageal reflux disease (GERD), NSAID-induced peptic ulcer, acid hypersecretory conditions including Zollinger-Ellison Syndrome, eradication of Helicobacter pylori (in combination with Antibiotics), ulcer resistant to H2 receptor antagonists.
Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus that persists longer than 24 hours.
Adult : PO GERD 20-40 mg for 4 wk, up to 8 wk if needed. Maintenance: 20-40 mg/day. Erosive oesophagitis 20-40 mg for up to 16 wk if needed. Peptic ulcer 40 mg for 2-4 wk (duodenal ulcer) or 4-8 wk for (benign gastric ulceration). Prophylaxis of NSAID-induced ulcers 20 mg. Zollinger-Ellison syndrome Initial: 80 mg. Max: 240 mg/day. Daily doses >80 mg should be given in 2 divided doses. All doses to be taken once daily in the morning. H.pylori infection 40 mg bid w/ clarithromycin and either amoxicillin or metronidazole. IV Zollinger-Ellison syndrome 80 mg once or twice daily until PO can be resumed. Max: 240 mg/day in divided doses. GERD; Peptic ulcer 40 mg/day until PO can be resumed.
No significant drug interactions have been observed in clinical studies.
Pantoprazole is contraindicated in patients with known hypersensitivity to the active drug or any other components of the formulation. Patients should be cautioned that Pantoprazole tablet should not be split, crushed or chewed.
Pantoprazole is well tolerated in both short term & long term treatment. Headache & diarrhoea are the most common side effects & rarely included abdominal pain, flatulence, rash, insomnia & hyperglycemia.
USFDA Pregnancy category B. Pantoprazole should be used during pregnancy only if clearly needed. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the benefit of the drug to the mother.
There are no known symptoms of overdosage in humans. Since Pantoprazole is highly protein bound, it is not readily dialyzable. Apart from symptomatic and supportive management, no specific therapy is recommended.
Keep in a dry place, away from light and heat. Keep out of the reach of children.
.png&w=384&q=75)