Indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, & tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, or Epidermophyton floccosum. It is indicated for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur.
This topical preparation contains the antifungal active compound Oxiconazole Nitrate. For topical dermatological use only. Oxiconazole Nitrate is an imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has in vitro activity against a wide range of pathogenic fungi. Oxiconazole has been shown to be active against most strains of the following organisms both in vitro and in clinical infections at indicated body sites: Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, Malassezia furfur. Oxiconazole exhibits satisfactory in vitro minimum inhibitory concentrations (MICs) against most strains of the following organisms: Microsporum audouini, Microsporum canis, Microsporum gypseum, Trichophyton tonsurans,Trichophyton violaceum.
It should be applied to affected & immediately surrounding areas once to twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. It should be applied once daily in the treatment of tinea (pityriasis) versicolor. Tinea corporis, tinea cruris, & tinea (pityriasis) versicolor should be treated for 2 weeks & tinea pedis for 1 month to reduce the possibility of recurrence.
Potential drug interactions between Oxiconazole and other drugs have not been systematically evaluated.
Potential drug interactions between Oxiconazole & other drugs have not been systematically evaluated.
Pruritus, burning, irritation & allergic contact dermatitis, folliculitis, erythema, & papules, fissure, maceration, rash, stinging & nodules.
Pregnancy category B. Because Oxiconazole Nitrate is excreted in human milk, caution should be exercised when the drug is administered to a nursing woman.
Store in a cool and dry place,protected from light. Do not freeze.
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