indicated for: Treatment of chronic idiopathic constipation in adults. Treatment of irritable bowel syndrome with constipation in women ? 18 years old.
Chloride channel activator
Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. Lubiprostone acts by specifically activating
ClC-2, which is a normal constituent of the apical membrane of the human intestine. By increasing intestinal fluid secretion, Lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with constipation. After administration, Lubiprostone and its metabolites are observed only on the apical (luminal) portion of the gastrointestinal epithelium. Additionally, activation of ClC-2 by Lubiprostone recovers mucosal barrier function via restoration of tight junction protein complexes. Lubiprostone relieves symptoms within 24 hours.
Chronic idiopathic constipation: 24 mcg taken twice daily orally with food and water. Reduce the dosage in patients with moderate and severe hepatic impairment. Irritable bowel syndrome with constipation: 8 mcg taken twice daily orally with food and water. Reduce the dosage in patients with severe hepatic impairment
Based upon the results of in vitro human microsome studies, there is low likelihood of drug-drug interactions. In vitro studies using human liver microsomes indicate that cytochrome P450 isoenzymes are not involved in the metabolism of Lubiprostone. Based on the available information, no protein binding–mediated drug interactions of clinical significance are anticipated.
Patients with known or suspected mechanical gastrointestinal obstruction should not receive Lubiprostone. Patients may experience nausea; concomitant administration of food may reduce this symptom. Do not prescribe for patients that have severe diarrhea.
Most common adverse reactions (incidence > 4%) in chronic idiopathic constipation are nausea, diarrhea, headache, abdominal pain, abdominal distension, and flatulence.
Pregnancy: Based on animal data, may cause fetal harm Nursing Mothers: Caution should be exercised when administered to a nursing woman.
Adverse reactions due to overdose are nausea, diarrhea, vomiting, dizziness, headache & abdominal pain.
Keep out of the reach of children. Store in a cool & dry place below 25°C, protect from light.
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