Loratadine is indicated for the symptomatic relief of allergy such as hay fever (allergic rhinitis), urticaria (hives), chronic idiopathic urticaria, and other skin allergies. For allergic rhinitis, loratadine is effective for both nasal and eye symptoms - sneezing, runny nose, and itchy or burning eyes.
H1-Receptor Antagonist: Antihistamine
This tablet is a preparation of Loratadine. Loratadine is a non-sedative histamine Hr receptor antagonist with antiallergic properties. Loratadine is a long-acting tricyclic antihistamine with selective peripheral Hi-receptor antagonistic activity and no central sedative or anticholinergic effect. It is rapidly effective and long-lasting, allowing once-a-day administration.
ORAL Allergic conditions: Adult: 1 0 mg once daily.ChiId: 2-5 yr: 5 mg once daily. 6-12 yr: 10 mg once daily.
There are no reports of potentially hazardous interactions with other drugs. In contrast to many other histamine H1 receptor antagonists, Loratadine has no potentiating effects when administered concurrently with alcohol, as measured by psychomotor performance studies. Concomitant therapy with drugs that inhibit or are metabolized by hepatic cytochromes P450 3A4 and 2D6 may elevate plasma concentrations of either drug and this mayifesult in adverse effects. Cimetidine inhibits both enzymes while erythromycin or ketoconazole inhibits P450 3A4. These drugs increase loratadine serum concentrations but no adverse effects are reported.
Pregnancy, lactation, child <2 yr. Severe hepatic damage, epilepsy, renal insufficiency.
Fatigue, giddiness, dizziness, dry mouth, headache, nausea, somnolence.
This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. Use is not recommended while breastfeeding.
In adults somnolence, tachycardia and headache have been reported with overdose greater than 10 mg. Extrapyramidal signs and palpitations have been reported in children with overdoses of greater than 10 mg. In the event of overdosage, general symptomatic and supportive measures should be instituted promptly and maintained for as long as necessary. It would seem reasonable to treat patients presenting early after large overdoses with oral activated charcoal. The conscious patients may be induced to vomit or gastric lavage may be performed.
Keep in a dry place away from light and heat. Keep out of the reach of children.
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