Indicated in the management of manifestations of psychotic disorders.
Phenothiazine; Antipsychotic
Fluphenazine is a phenothiazine, also called a neuroleptic, used to treat symptoms of a certain type of mental/mood condition (schizophrenia).
ORAL Psychoses; Mania; Schizophrenia: Adult: Initially, 2.5-10 mg daily in 2-3 divided doses, increased according to reponse. Maintenance: 1-5 mg daily. Max Dose: Adult: 20 mg/day. Elderly: 10 mg/ day. Short-term adjunct In severe anxiety or behavioral disturbances: Adult: 1mg bid increased to 2 mg bid if necessary. INTRAMUSCULAR Psychoses; Mania; Schizophrenia: Adult: As decanoate: Initially, 12.5 mg adjusted according to response. Maintenance: 12.5-100 mg at intervals of 2-6 wk. For doses >50 mg, increments should be made slowly in steps of 12.5 mg. The enantate ester can be given in similar doses at intervals of 1-3 wk. Elderly: 6.25 mg adjusted according to response.
Interactions with barbiturates, alcohol, and narcotic drugs may occur, so central depressants should be administered with caution.
Hypersensitivity; comatose or severely depressed states; blood dyscrasias; liver disease; bone marrow depression; phaeochromocytoma; suspected or established subcortical brain damage w/or w/o hypothalamic damage; pregnancy (3rd trimester), lactation. Presence of convulsive disorders; hepatic, renal. cerebrovascular, resp & CV diseases; elderly or debilitated patients. May elevate prolactin levels which may persist after chronic admin. May exacerbate depression. Closed- angle glaucoma. History of jaundice, parkinsonism, DM, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Regular eye examinations in patients receiving long term therapy. Avoid direct sunlight exposure.
Tardive dyskinesia, sedation, mental confusion; hypotension; hyperprolactinaemia leading to galactorrhoea & amenorrhoea in women; loss of libido, impotence & sterility in males. Allergic reactions. cholestatic jaundice, corneal & lens deposits, skin pigmentation. Agranulocytosis; neuroleptic malignant syndrome.
This drug may cause problems in newborns if it is taken during the last months of pregnancy. Studies also suggest that taking antipsychotic medications during pregnancy can lead to birth defects. The risk seems to be highest if these drugs are taken during the first trimester. There is no published experience with fluphenazine during breastfeeding. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. Because of the lack of published experience with fluphenazine during breastfeeding, other antipsychotic agents may be preferred, especially wile nursing an newborn or preterm infant. Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
.png&w=384&q=75)