Pain/Fever/Dysmenorrhea. Osteoarthritis, Rheumatoid Arthritis and other inflammatory disease.
Prostaglandin synthesis inhibitor; NSAID
Ibuprofen has a high level of anti-inflammatory, anti-pyretic, and analgesic activity. The analgesic effects of Ibuprofen are due to both a peripheral and a central effect. Ibuprofen is a potent inhibitor of the enzyme cyclooxygenase, which thus results in a marked reduction in prostaglandin synthesis. Ibuprofen also inhibits the synthesis of some lipo-oxygenase products. Ibuprofen thus quickly relieves pain and stiffness, reduces swelling, and improves the movement of different joints of arthritis sufferers.
ORAL Pain & inflammation: Adult: 1.2-1.8 g/ day in divided doses. Maintenance: 0.6- 1.2 g daily. Max: 2.4 g/day. Juvenile idiopathic arthritis: Child: 3 mth & weighing >5 kg: 30-40 mg/kg/day in 3-4 divided doses. Max: 2.4 g/day. Fever: Adult: 200-400 mg every 4-6 hr. Max: 1.2 glday. Child: 1-6 mth: 5 mg/kg 3-4 times daily, 6-12 mth: 50 mg 3 times daily, 1-2 yr: 50 mg 3-4 times daily, 2-7 yr: 100 mg 3-4 times daily, >7 yr: 200 mg 3-4 times daily. Max: 40 mg/kg/day. INTRAVENOUS Closure of patent ductus arteriosus: Child: Given as three IV doses infused over 15 mins at 24-hr intervals. Initially 10 mg/ kg followed by two doses of 5 mg/ kg. A 2nd course may be given if ductus remains open after 48 hr. Surgery may be required if neonate is unreponsive to 2 courses of treatment. Dose should be based on birth weight.
Caution should be taken in concomitant use with the medications which could increase the risk of ulceration or bleeding. Concomitant use with acetylsalicylic acid is not recommended. Co-administration with other NSAIDs and high doses of methotrexate should be avoided. Caution should be taken in concomitant use with ACE inhibitors, diuretics, lithium, anti-platelet agents, warfarin, aminoglycosides, corticosteroids, cyclosporin, tacrolimus, mifepristone, quinolone, zidovudine, voriconazole and fluconazole.
Active peptic ulcer; hypersensitivity. Neonates w/ congenital heart disease, suspected necrotising enterocolitis & active bleeding (parenteral). Asthma; renal or hepatic disorders; bleeding disorders; CV disease. Pregnancy, lactation.
Oral: Dyspepsia, vomitting, abdominal pain, heart burn, nausea, diarrhoea. epigastnc pain, edema, fluid retention, dizziness, rash, tinnitus. Parenteral: Intraventricular hemorrhage, skin irritation, hypocalcemia, hypoglycemia, GI disorders, anemia, apnea, resp infection, sepsis. Severe CV thrombotic events. Severe GI bleeding, ulceration & perforation.
It's best to avoid taking ibuprofen in the first 30 weeks of pregnancy, unless the benefits outweigh the potential risk to your unborn baby. This is because taking ibuprofen in the first 30 weeks of pregnancy may lead to an increased risk of complications, including miscarriage. Only a small amount gets into your breastmilk and it's unlikely to harm your baby. Take ibuprofen for the shortest time possible and stick to the recommended dose.
In case of overdose, gastric lavage and if necessary, correction of serum electrolytes have been recommended. There is no specific antidote for ibuprofen.
Store below 30°C in a dry place, protected from light. Keep away from the reach of children.
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