Indicated for the management of the signs and symptoms of osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis in patients 2 years and older, and ankylosing spondylitis; for the management of acute pain in adults, and for the management of primary dysmenorrhea.
COX-2 Inhibitor; NSAIDs/ Antirheumatoid Drug
Celecoxib is a non-steroidal anti-inflammatory agent (specific COX-2 inhibitor) having marked anti-inflammatory, analgesic and antipyretic activities with lower incidence of gastrointestinal adverse effects.
ORAL Osteoarthritis: Adult: 200 mg as a single dose or in 2 divided doses. May increase to 200 mg 2 times if necessary. Rheumatoid arthritis: Adult: 100-200 mg bid. Eldedy 100 mg bid. Dysmenorrhoea;PaIn relief: Adult: Initially, 400 mg followed by 200 mg if necessary on the 1st day. Maintenance: 200 mg bid. Familial adenomatous polyposis: Adult: 400 mg bid.
Hypersensitivity including those in whom attacks of angioedema, rhinitis & urticaria have been precipitated by aspirin, NSAIDs or sulfonamides. Severe hepatic impairment; severe heart failure; inflammatory bowel disease; peptic ulcer; renal impairment (creatinine clearance <30 mLlmin); pregnancy & lactation. History of Gl bleeding; renalfhepatic insufficiency; asthma or allergic disorders; hypertension; monitor Hb or haematocrit levels for signs of anaemia, History of cerebrovascular disease or lschaemic heart disease (IHD).
Abdominal pain, diarrhea, nausea, oedema, dizziness, headache, insomnia, upper resp tract infections (URTI); rash. Serious skin reactions such as exfoliative dermatitis, Stevens-Johnson syndrome, & toxic epidermal necrolysis.
This drug should not be used starting at 30 weeks gestation as it may cause premature closure of the ductus arteriosus. Breastfeeding is not recommended.
Patients should be managed by symptomatic and supportive care following an NSAID overdose. There are no specific antidotes. No information is available regarding the removal of Celecoxib by hemodialysis but based on its high degree of plasma protein binding (>97%) dialysis is unlikely to be useful in overdose. Emesis and/or activated charcoal and/or osmotic cathartic may be indicated in patients seen within 4 hours of ingestion with symptoms or following a large overdose. Forced diuresis, alkalinization of urine, hemodialysis or hemoperfusion may not be useful due to high protein binding.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
.png&w=384&q=75)