Upper and lower respiratory and urinary tract infections; skin, soft tissue, bone and joint infections; septicemia, meningitis, peritonitis, cholecystitis, cholangitis, pelvic inflammatory disease, endometritis, gonorrhea, and other abdominal and genital tract infections.
Cefoperazone is a bactericidal Cephalosporin antibiotic which is resistant to most beta-lactamases and active against a wide range of aerobic & anaerobic, Gram positive & Gram negative bacteria. The bactericidal action of Cefoperazone results from the inhibition of bacterial cell wall synthesis. Cefoperazone has a high degree of stability in the presence of beta-lactamases produced by most Gram negative pathogens. Cefoperazone is usually active against organisms which are resistant to other beta-lactam antibiotics because of beta-lactamase production.
The usual adult daily dose of it is 2 to 4 grams per day administered in equally divided doses every 12 hours. In severe infections or infections caused by less sensitive organisms, the total daily dose and/or frequency may be increased. Patients have been successfully treated with a total daily dosage of 6?12 grams divided into 2, 3, or 4 administrations ranging from 1.5 to 4 grams per dose. When treating infections caused by Streptococcus pyogenes, therapy should be continued for at least 10 days.
Clostridium difficile infection. Inadequate Vitamin K. Decrease in the Blood-Clotting Protein Prothrombin. increased risk of bleeding due to clotting disorder. alcohol intoxication. liver problems.
diarrhea, nausea, vomiting, hypersensitivity skin reactions including rash, injection site reactions (pain, swelling, or redness), or. reversible low white blood cell count (neutropenia).
Cefoperazone has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Cefoperazone should only be given during pregnancy when need has been clearly established. Cefoperazone is excreted into human milk in small amounts. Adverse effects in the nursing infant are unlikely. Other cephalosporins have been classified as compatible with breast-feeding by the American Academy of Pediatrics.
Cefoperazone is to be stored in a dry place, below 25°C and protected from light prior to reconstitution. The reconstituted solution may be stored for 24 hours if kept in room temperature (below 25°C).
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