This is indicated for dyspepsia, hyperacidity, gastric and duodenal ulcer, gastritis; also indicated for the relief of flatulence, abdominal distention and windy colic.
This is the mixture of non-systemic acid neutralizing substances and antiflatulent. This preparation offers reliability as well as long action. Aluminium Hydroxide and Magnesium Hydroxide induce the relief of ulcer by neutralizing gastric acid secreted from parietal cells of the stomach. The clinical use of simethicone is based on its antifoam properties. Simethicone spreads on the surface of aqueous liquids, forming a film of low surface tension and causing collapse of foam bubbles. Simethicone repeatedly allows mucous surrounded gas bubbles in the GI tract to coalesce and be expelled.
This is used in the treatment of flatulence and meteorism for the elimination of gas, air or foam from the gastro-intestinal tract prior to radiography and for the relief of abdominal distension and dyspepsia.
Simethicone is physiologically inert; it does not appeared to be absorbed from the GI tract to interfere with gastric secretion or absorption of nutrients. Following oral administration, the drug is excreted unchanged in the feces.
Tablet: 1-2 tablets 1-3 hours after meal and at bed time or as directed by the physician. Suspension: 1-2 teaspoonful 1-3 hours after meal and at bedtime or as directed by the physician.
All antacids may increase or decrease the rate and/or extent of absorption of concomitantly administered oral drugs. Antacids decrease the bioavailability of theophyline, tetracycline, quinolone antibiotics, isoniazide, ketoconazole, ethambutol, some antimuscarinic drugs, benzodiazepines, phenothiazines, ranitidine, indomethacine, nitrofurantoin, fluoride, phosphate, propanolol, atenolol, digoxins, vitamins etc. Antacids increase the bioavailability of some drugs; e.g. sulphonamides, levodopa, valproic acid, enteric coated aspirin etc.
Drugs containing Aluminum Hydroxide should not be taken concomitantly with any form of tetracycline, as the absorption of the later may be affected. Aluminum Hydroxide may also reduce the absorption of Digoxin.
Gastrointestinal side effects are uncommon. Occasionally, if excessive amount is consumed, diarrhea, constipation or regurgitation may occur.
It is advised to avoid antacid preparations in the first trimester of pregnancy.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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