Vitamin B complex + Vitamin C

Supplement for daily requirements of the water-soluble vitamins in infants,children and adults.

Specific combined vitamin preparations

Vitamin B-Complex and Vitamin C function as cofactors of various enzymes which regulate carbohydrate, protein and fat metabolism. Thiamine (B1) acts as a cofactor in the decarboxylation of keto acids such as pyruvic acid. Riboflavin (B2) plays a vital role in cellular respiratory reactions in conjunction with nicotinamide. Pyridoxine (B6) takes part in decarboxylation and interconversion of amino acids. It is also required for normal antibody-mediated and cell-mediated immune responses. Vitamin B12 (cyanocobalamin) is required for synthesis of DNA (deoxyribo-nucleic acid) and maturation of RBCs (red blood cells). Nicotinamide plays a vital role in cellular respiration in conjunction with riboflavin. Calcium Pantothenate functions as a cofactor for enzymes involved in transfer of acetyl groups. It is also required for normal antibody response in conjunction with pyridoxine. Folic acid, after conversion in the body to folinic acid, takes part in reactions involved in the synthesis of nucleotides and maturation of RBCs in conjunction with vitamin B12. It also plays an important role in lymphocyte-mediated immune response. Ascorbic acid (Vitamin C) takes part in biochemical reactions involving oxidation, as in collagen synthesis, and in conversion of folic acid to folinic acid. It is also necessary for normal phagocytic function ofWBCs (white blood cells). Thus an adequate supply of these water-soluble vitamins is required for the optimum function of various cells and tissues.Except for Vitamin B12, these water-soluble vitamins are not stored in the body to any significant extent, the excess quantities being excreted in the urine. Therefore, a regular and adequate intake of them is necessary to meet the metabolic requirements. Deficiencies of water-soluble vitamins often co-exist because of their overlapping dietary sources and metabolic interdependence. Initially the deficiency of these vitamins may be subclinical and demonstrable only by means of biochemical tests. If not corrected at this stage, it may become manifest as various symptoms, including impaired wound healing and increased susceptibility to infection. Classical deficiency diseases such as beri beri, pellagra and scurvy are rare, whereas mild and subclinical deficiencies are probably more common, even among apparently healthy individuals.

Adults: For adult patients and children weighing 10 kg or more,the recommended daily doses are the content of 1 vial (10 ml). Children: Children weighing less than 10 kg should be given 1/10 of the content of one vial i.e. 1 ml per kg body weight per day. Instructions for use or handling: Adults and children weighing 10 kg or more: The contents of one vial are dissolved by the aseptic addition of 10 ml of one of the following: 1. Water for injection. 2. Fat emulsion (10%). 3. Glucose solution,electrolyte-free (5% to 60%) Children below 10 kg: The contents of one vial are dissolved by aseptic addition of 10 ml of one of the above 3 solutions. But the dose should be given as 1 ml of the dissolved mixture per kg body weight per day. Arovital IV Injection may be added to parenteral nutrition admixtures containing carbohydrates,lipids,amino acids,electrolytes and trace elements provided that compatibility and stability have been confirmed.

Folic acid may lower the serum concentration of phenytoin. Pyridoxine can reduce the effect of levodopa.

Hypersensitivity to any of the ingredients of the preparation.

Since Arovital IV Injection has to be diluted with other nutrient solutions,it may cause unwanted effects in some people. The unwanted effects of nutrient solutions are a rise in the body temperature,shivering,chills and nausea and vomiting. Other rare unwanted effects include: allergic reactions; breathing difficulties (rapid breathing,shortness of breath); effects on blood pressure,abdominal pain,tiredness,headaches,flushing,slight pressure over the eyes and dizziness.

Animal reproduction studies or clinical investigations during pregnancy have not been carried out with this preparation

Store in a cool and dry place, away from light and children.

Each capsule contains- Ascorbic Acid BP 175.0 mg Calcium D-Pantothenate BP 25.0 mg Cyanocobalamin BP 5 mcg Folic Acid BP 500 mcg Thiamine Mononitrate USP 50.0 mg Riboflavin BP 25.0 mg Pyridoxine Hydrochloride BP 10.0 mg Nicotinamide BP 100.0 mg