Treatment & relief of symptoms associated with irritable bowel syndrome (spastic colon) Postoperative paralytic ileus in order to accelerate the resumption of the intestinal transit following abdominal surgery.
Synthetic anticholinergic agent
Trimebutine Maleate is a noncompetitive spasmolytic agent.lt possesses moderate opiate receptor affinity and has marked anti-serotonin activity especially on 'mu' receptors. It induces regulation of spontaneous activity and increases synchronization between electrophysiological spikes and contractions in isolated guinea pig strips of colon and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity.
For adults: 100mg-200mg, 3 times per day before meals.
No other drug interactions have been observed during clinical trials or otherwise reported.
Patients with known hypersensitivity to trimebutine maleate or any excipient.
GI effects such as constipation, diarrhoea, thirst; palpitations; sleepiness, dizziness, lassitude, headache; hypersensitivity.
The use of trimebutine maleate in pregnant women is recommended. It is not known if trimebutine maleate passes into breast milk. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.
No evidence of overdosage have been reported to date. However, if overdosage should occur following oral administration, gastric lavage is recommended. Treatment should be made according to the symptoms observed.
Store in a cool and dry place,away from light and moisture.
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