(tretinoin) Gel microsphere, 0.1%, 0.08% and 0.04%, is a retinoid, indicated for topical treatment of acne vulgaris
Topical retinoid and related preparations
Although the exact mode of action of Tretinoin is unknown, current evidence suggests that topical Tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally Tretinoin stimulates mitotic activity and increases turnover of follicular epithelial cells, causing extrusion of the comedones, papules and pustules.
Apply a thin layer of it once daily, before bedtime, to skin where lesions occur. Keep away from eyes, mouth, nasal creases, and mucous membranes. x Not for oral, ophthalmic, or intravaginal use
Other topical acne treatments should be used with caution during treatment with Tretinoin. Particular caution should be exercised when using preparation containing a peeling agent for example benzoyl peroxide. It is also possible to apply Tretinoin and benzoyl peroxide alternately. The suggested regimens are either Tretinoin in the morning and benzoyl peroxide in the evening or the preparations should be used on alternate days.
Other topical acne treatments should be used with caution during treatment with Tretinoin. Particular caution should be exercised when using preparation containing a peeling agent for example benzoyl peroxide. It is also possible to apply Tretinoin and benzoyl peroxide alternately. The suggested regimens are either Tretinoin in the morning and benzoyl peroxide in the evening or the preparations should be used on alternate days.
Most common adverse reactions are skin pain, pruritus, skin irritation/subcutaneous irritation, pharyngitis, and erythema.
It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies in pregnant and nursing women
Application of larger amounts of medication than recommended has not been shown to lead to
more rapid or better results, and marked redness, peeling, or discomfort may occur. Oral
ingestion of the drug may lead to the same side effects as those associated with excessive oral
intake of Vitamin A.
Keep out of the reach of children. Keep in a cool & dry place, protect from light.
.png&w=384&q=75)