To prevent & treat osteoporosis in postmenopausal women. To increase bone mass in men with osteoporosis. To prevent & treat osteoporosis in men & women that is caused by treatment with steroid medicines such as prednisolone. To treat Paget$#$#$#$s disease of bone in men & women.
Bisphosphonate preparations
Your body is constantly breaking down old bone and making new bone tissue. If you have osteoporosis, your body breaks down more bone than it forms so gradually bone loss occurs and your bones become thinner and fragile. This is especially common in women after menopause (change of life). Many people with osteoporosis have no symptoms and you may not even know that you have it. However, osteoporosis makes you more likely to have fractures (break bones), especially in your spine, hips and wrists.
Risedronate has an affinity for hydroxyapatite crystals in bone and acts as an antiresorptive agent. At the cellular level, Risedronate inhibits osteoclasts. The osteoclasts adhere normally to the bone surface, but show evidence of reduced active resorption. Calcium suppresses parathyroid hormone (PTH) secretion and decreases bone turnover. Increased levels of PTH are known to contribute to age-related bone loss, especially at cortical sites, while increased bone turnover is an independent risk factor of fractures.
One Risedronate tablet should be taken orally once a week (Day 1 of the 7-day treatment cycle). One calcium 500 mg tablet should be taken orally with food daily on each of the remaining six days (Days 2 through 7 of the 7-day treatment cycle). The following instructions are applicable to all patients taking Risedronate tablet: Take Risedronate tablet exactly as prescribed by your healthcare provider At first take Risedronate tablet in the morning before you eat or drink anything except plain water. Take Risedronate tablet while you are sitting up or standing. Take a Risedronate tablet with 1 glass of plain water. Do not take it with any other drink besides plain water. Swallow whole Risedronate tablet. Do not chew the tablet or keep it in your mouth to melt or dissolve. After taking Risedronate tablet you must wait at least 30 minutes before: 1. lying down. You may sit, stand, or do normal activities. 2. eating or drinking anything except plain water. 3. taking vitamins, calcium, or antacids. 4. Take vitamins, calcium, & antacids at a different time of the day from when you take Risedronate tablet. 5. Keep taking Risedronate tablet for as long as your healthcare provider tells you.
Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription specially aspirin or other NSAIDs. Antacids, supplements, or medicines that contain aluminum, calcium, magnesium, or other minerals can interfere with the absorption of Risedronate Sodium. If you use these other medicines, do not take these for at least 30 minutes after taking a Risedronate Sodium tablet.
Take special care with if you: have low blood calcium (hypocalcemia). cannot sit or stand up for 30 minutes. have kidneys that work poorly. have an allergy to Risedronate Sodium. are pregnant or may become pregnant. are breast-feeding or plan to breast-feed. have kidney problems, Risedronate Sodium may not be right for you. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription specially aspirin or other NSAIDs. Antacids, supplements, or medicines that contain aluminum, calcium, magnesium, or other minerals can interfere with the absorption of Risedronate Sodium. If you use these other medicines, do not take these for at least 30 minutes after taking a Risedronate Sodium tablet.
Chest pain, difficulty or pain when swallowing, pain or burning under the ribs or in the back, new or worsening heartburn, severe joint, bone, or muscle pain, jaw pain, numbness, or swelling, mild heartburn or stomach upset, diarrhea, gas, or constipation, mild joint or back pain, headache.
Pregnancy Category C. It is only intended for use in postmenopausal women. It is not known whether Risedronate is excreted in human milk. It should not be given to nursing women.
Store in a cool and dry place. Protect from light & moisture. Keep out of the reach of children.
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