It is indicated for the eradication of H. pylori in active chronic gastric, duodenal and gastric ulcers.
Amoxicillin is similar to penicillin in its bactericidal action against susceptible bacteria during the stage of active multiplication. It acts through the inhibition of cell wall biosynthesis that leads to the death of the bacteria.
Clarithromycin acts by inhibiting microsomal protein synthesis in susceptible organisms mainly by binding to the donor site on the 50S subunit of the bacterial ribosome and preventing translocation to that site.
Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+,K+ ATPase at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion.
Twice daily for 7-14 days or as per the physician$#$#$#$s advice.
Clarithromycin use in patients who are receiving theophylline may be associate with increase of serum theophylline concentrations. There have been reports of interactions of clarithromycin with carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfetanil, disopyramide, lovastatin, bromocriptine, valproate,terfenadine, cisapride, pimozide & astemizole.
Clarithromycin use in patients who are receiving theophylline may be associate with increase of serum theophylline concentrations. There have been reports of interactions of clarithromycin with carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfetanil, disopyramide, lovastatin, bromocriptine, valproate,terfenadine, cisapride, pimozide & astemizole.
It is contraindicated in patients with known hypersensitivity to any of its component.
Adverse reactions which were reported as possibly or probably related to treatment (>3%) in clinical trials when all three components of this therapy were given concomitantly are listed below and devided by body systems. Digestive system: Nausea, vomitng, diarrhoea, dark stools, dry mouth, glossitis, oral moniliasis, stomatitis, tongue discoloration ; Musculoskeletal System - myalgia; Nervous System - confusion, headache, dizziness; Skin - skin reactions; Urogenital System - vaginitis, vaginal moniliasis.
It should be used during pregnancy only if the potential benefit justifies the potential risk of the mother. Amoxycillin is excreted in human milk in very small amounts. Because of the potential for serious adverse reactions in nursing infants from It's a decision should be made whether to discontinue nursing or to discontinue the drug therapy, taking into account the importance of the therapy to the mother.
There has been no experience of overdoses with Rabeprazole. In case of overdosage of Amoxicillin, medication is discontinued, treatment should be symptomatic and supportive measures are institued as required. Overdosage of Clarithromycin can cause gastrointestinal symptoms such as abdominal pain, vomiting, nausea and diarrhea.
Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.
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