This medication is used to treat intestinal worm infections such as pinworm, roundworm, and hookworm.
Pyrantel Pamoate pamoate acts as a depolarizing neuromuscular blocking agent, thereby causing sudden contraction, followed by paralysis, of the helminths. This has the result of causing the worm to "lose its grip" on the intestinal wall and be passed out of the system by natural process. Since Pyrantel is poorly absorbed by the host's intestine, the host is unaffected by the small dosage of medication used. Spastic (tetanic) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm load. This obstruction is usually in the form of a worm impaction and happens when a very small, but heavily parasitized animal is treated and tries to pass a large number of dislodged worms at once. Worms usually pass in normal stool or with diarrhea, straining, and occasional vomiting.
ORAL Single or mixed infections due to susceptible worms: Adult: 10 mg/kg as a single dose. Child: 10 mg/kg as a single dose. Ascariasis: Adult: 5 mg/kg as a single dose. Max: 1g/dose. For mass treatment programmes: 2.5 mg/kg as a single dose given 3-4 times a yr. Necatoriasis: Adult: 10 mg/kg daily for 3-4 days or 20 mg/kg daily for 2 days. Enterobiasis: Adult: 10 mg/kg repeated once after 2-4 wk. Max dose: 1g/dose. Trichinosis: Adult: 10 mg/kg daily for 5 days.
Liver dysfunction, anaemia or severe malnutrition. Treat members in close contact w/ the patient.
Anorexia, nausea, vomiting, abdominal cramps, drowsiness, insomnia, diarrhoea, tenesmus, SGOT elevations, headache, dizziness, rash.
There are no controlled data in human pregnancy. Pyrantel is only recommended for use during pregnancy when benefit outweighs risk. There are no data on the excretion of pyrantel into human milk.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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