Symptomatic relief of gastro-intestinal disorders characterised by smooth muscle spasm,Adult enuresis
Anticholinergics (antimuscarinics)/ Anti-spasmodics
Propantheline Bromide acts by dual mechanism of action.
Specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites
Direct effect upon smooth muscle (musculotropic).
This medication is a muscarinic antagonist having antispasmodic properties. It reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle. It also has a direct relaxing effect on smooth muscle. In addition, Propantheline inhibits gastrointestinal motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. Other secretions like pancreatic juice, sweat and saliva are also reduced.
Adult dose: The usual initial adult dose of propantheline bromide tablets is 15 mg taken 30 minutes before each meal and 30 mg at bedtime (a total of 75 mg daily). Subsequent dosage adjustment should be made according to the patient’s individual response and tolerance. Pediatric Use: Safety and effectiveness in children have not been established.
Antacids or Absorbent Antidiarrhoeals may reduce the absorption of propantheline bromide, therefore resulting in a reduction of its therapeutic effectiveness. Therefore, take two to three hours apart from doses of propantheline bromide. Anticholinergics may delay absorption of other medication given concomitantly. Significant drug interaction also occurs with concomitant use of digoxin, haloperidol, corticosteroides, ketoconazole, levodopa, opioid analgesics, phenothiazines, urinary alkalizers.
Propantheline is contraindicated in patients with: Glaucoma,since mydriasis is to be avoided. Obstructive disease of the gastrointestinal tract (pyloroduodenal stenosis,achalasia,paralytic ileus,etc.). Obstructive uropathy (e.g.,bladder-neck obstruction due to prostatic hypertrophy). Intestinal atony of elderly or debilitated patients. Severe ulcerative colitis or toxic megacolon complicating ulcerative colitis. Unstable cardiovascular adjustment in acute hemorrhage. Myasthenia gravis.
Ophthalmic side effects include blurred vision,mydriasis,cycloplegia,and increased ocular tension. Other reported adverse reactions include urinary hesitancy and retention,tachycardia,palpitations,loss of the sense of taste,headache,nervousness,mental confusion,drowsiness,weakness,dizziness,insomnia,nausea,vomiting,constipation,bloated feeling,impotence,suppression of lactation,and allergic reactions or drug idiosyncracies including anaphylaxis,urticaria and other dermal manifestations.Decreased sweating.
Pregnancy Category C. Animal reproduction studies have not been conducted with propantheline. It is also not known whether propantheline can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Propantheline should be given to a pregnant woman only if clearly needed. Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk,caution should be exercised when propantheline is administered to a nursing woman. Suppression of lactation may occur with anticholinergic drugs.
The symptoms of overdosage with Propantheline Bromide progress from an intensification of the usual side effects (from nausea and vomiting) to CNS disturbances (from restlessness and excitement to psychotic behaviour), circulatory changes, (flushing, fall in blood pressure, circulatory failure), respiratory failure, paralysis.
Do not store above 30°C. Keep away from light and out of the reach of children.
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