It is indicated for the treatment or prevention of any infection caused by Penicillin sensitive bacteria where a long acting Penicillin is required. It is indicated in- Gonorrhoea caused by Penicillin sensitive microorganisns Prevention of endocarditis during dental procedures Gas-gangrene following amputation
Benzylpenicillin & Phenoxymethyl penicillin
All beta lactum antibiotics bind to bacterial cell receptors. These receptors are involved in the cross-linking of peptide side chain-transpeptidation reaction. Gram-positive bacteria have more receptors for beta lactums than gram-negative organisms. After beta lactums have attached to the cell receptors, peptidoglycan synthesis (cell wall) is inhibited because the activity of transpeptidation enzyme is blocked leads to the formation of defective cell wall that are osmotically unstable. Cell death result from cell lysis.
Add 3 ml of water for injection and shake vigorously. Adults: 4,00,000 units once daily or twice daily. Children: Over 25 kg as for adults; under 25 kg reduce proportionally. In severe cases dose may be doubled. Intramuscular injection is the only route of administration of Procaine Penicillin.
Hypersensitivity to penicillin. Hypersensitivity to cephalosporins. Renal impairment. CHF. Infant. Elderly.
Allergic reactions may occur but usually resolve on cessation of therapy.
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1st trimester.
Store in a cool & dry place. Protect from sunlight & moisture. Keep out of reach of children.
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