Prophylactic treatment of recurrent vascular headaches including classical migraine common migraine & cluster headache.
Antihistamine; Antimigraine drug
Pizotifen works by inhibiting the peripheral actions of serotonin and histamine in increasing the membrane permeability of cranial vessels and transudation of plasmakinin, while altering pain thresholds in migraines. By blocking 5-HT receptors, pizotifen attenuates the signalling of serotonin in causing cranial vasoconstriction, as well as serotonin-enhanced platelet function and aggregation. There is evidence that it also inhibits the peripheral actions of bradykinin. Pizotifen may inhibit serotonin reuptake by blood platelets, which affects the tonicity and decreases passive distension of extracranial arteries. The effects of pizotifen leading to appetite stimulation may be due to the drug acting at the metabolic level rather than a direct stimulation of the appetite centre.
1.5 mg daily at bed time as a single dose or in three divided doses.
The central effects of sedatives, hypnotics, antihistamines (including certain common cold preparations) and alcohol may be enhanced by Pizotifen. Pizotifen antagonizes the hypotensive effect of adrenergic neurone blockers.
Hypersensitivity, narrow-angle glaucoma or prostate hypertrophy. Dosage adjustment may be necessary in patients with kidney insufficiency.
Drowsiness, dizziness, dry mouth, nausea & constipation
Clinical data with pizotifen in pregnancy are very limited; it should be administered in pregnancy only if the expected benefits outweigh the potential risks.
Keep in a dry place away from light and heat. Keep out of the reach of children.
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