Abdominal pain, Colic, Gastrointestinal tract spasm, Peptic ulcer disease, Visceral spasms
Anticholinergic; Antispasmodic Agent
Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Oxyphenonium is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Oxyphenonium inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Adult: 1-2 tablets 3-4 times daily Children: ½- 1 tablets 1-3 times daily
Reduced gastric motility interferes with absorption of other drugs. Effects potentiated by other antimuscarinics including amantadine, some antihistamines, phenothiazines and TCA.
Urinary outflow obstruction, paralytic ileus, myasthenia gravis. Children; elderly; benign prostatic hyperplasia; acute MI, cardiac failure, hypertension, thyrotoxicosis; pregnancy and lactation; fever; angle-closure glaucoma.
Dryness of mouth, difficulty in talking/swallowing; reduced bronchial secretions; blurring of vision, photophobia; bradycardia followed by tachycardia and arrhythmias; urinary retention, constipation, vomiting, nausea; confusion and giddiness.
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Treatment is the same as for atropine overdosage.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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