Indicated for the relief of symptoms of depression.
Tricyclic; Antidepressant
Nortriptyline hydrochloride is a tricyclic antidepressant. Nortriptyline inhibits the uptake of norepinephrine and serotonin at nerve terminals. In contrast to its parent compound amitriptyline which is equally potent in inhibiting the uptake of norepinephrine and serotonin, Nortriptyline has a greater effect on norepinephrine reuptake than on serotonin reuptake. Fluphenazine is a tranquilizer of the phenothiazine type with piperazine side chain. Fluphenazine primarily acts as a neuroleptic drug whose main therapeutic effect is believed to reside in potent dopamine (specially D2) receptor antagonism.
ORAL Depression: Adult: 75-100 mg daily in 3-4 divided doses, increased gradually up to 150 mg daily in severe depression. Child: Adolescent: 30-50 mg daily in divided doses. Elderly: 30-50 mg daily in divided doses. Nocturnal enuresis: Child: 6-7 yr (20-25 kg): 10 mg; 8-11 yr (25-35kg): 10-20 mg; >11 yr (35-54 kg): 25-35 mg. All doses are given 30 mins before bedtime & treatment should continue for not >3 mth.
Interactions with barbiturates, alcohol, and narcotic drugs may occur, so central depressants should be administered with caution.
Mania, recent Ml, arrhythmias (particularly heart block); severe liver disease; child <6 yr. Elderly; hepatic or renal dysfunction; benign prostatic hypertrophy; angle closure glaucoma; phaeochromocytoma; CVS disease; epilepsy; history of bowel obstruction; w/draw gradually; monitor for suicidal tendencies during early treatment; DM; thyroid disease; psychoses (may aggravate psychotic symptoms); urinary retention. Pregnancy, lactation.
Tachycardia, slows conduction & prolongation of PR interval, lowers seizure threshold, peripheral neu ropathy, dry mouth, constipation, urinary hesitancy, confusion & blurred vision, nausea, sweating, tremor, rashes, hypersensitivity reactions, hypomania or mania, headache, hyponatraemia, abnormal LFT, endocrine disorders, movement disorders, taste disturbances. Rare, blood dyscrasias.
Animal studies have revealed inconclusive fetal harm results. There are no controlled data in human pregnancy. Benefit should outweigh risk for Breastfeeding.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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