It is indicated in the following conditions: 1. To prevent convulsion in patients with preeclampsia, eclampsia, tetanus and acute uraemia. 2. In acute myocardial infarction, arrythmia. 3. To arrest premature labour. 4. As an adjuvant in neurosurgery to lower the C.S.F pressure. 5. For replacement therapy in hypomagnesaemia 6. To control hypertension, encephalopathy and convulsion associated with acute nephritis in children. Dosage and Administration
Oral electrolytes preparations, Other laxative preparations, Specific mineral preparations
Usual dose range: Upto 40 g daily at a rate not exceeding 3 ml per minute Seizure prophylaxis in Preeclampsia and Eclampsia : A loading dose of 4g (100 ml) over upto 20 minutes followed by a maintenance dose of 2g (50ml) per hour. Recurrence of seizure may require an additional I.V bolus of 8-16 mmol ( upto 100ml ). For seizure prophylaxis, treatment should continue during labour and for atleast 24 hours after delivery. In Myocardial infarction : 8 mmol (50ml) over 20 minutes, then 65 mmol (400ml) over 24 hours. In Magnesium deficiency : 0.5-1 mmol / kg/day (200ml to 400ml) on the first day followed by 25 mmol (150ml) daily, upto 160 mmol (1000ml) over upto 5 days. In Tetanus : An infusion of Magnesium Sulphate sufficient to maintain a blood magnesium concentration of 2.5 to 4 mmol per litre has been recommended. In arrythmia : 8 mmol (50 ml) over 10-15 minutes (repeated once if needed)
It is contraindicated in patients with heart block or myocardial damage.
Excessive administration of magnesium results in hypermagnesaemia manifested by nausea, vomiting, flushing of the skin, thirst, hypotension, drowsiness, confusion, loss of tendon reflexes, respiratory depression, cardiac arrest etc.
Magnesium Sulphate crosses the placenta. So, as with any other drugs, caution is required when the drug is administered to pregnant women. It is not known whether the drug is excreted in human milk. As it happens with many other drugs, cautions should be taken when it is administered to a nursing mother.
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