Used in the treatment of gynecological disorders such as menstrual disorders
Female Sex hormones,Oral Contraceptive preparations
Lynestrenol is an oral preparation of the synthetic progestagen lynestrenol, which shares various activities with the natural hormone progesterone. Lynestrenol has a strong progestational influence on the endometrium. In addition, it suppresses ovulation and menstruation for as long as the preparation is taken daily without interruption. Lynestrenol can be used in conditions requiring a pronounced progestagenic effect. After oral administration lynestrenol is readily absorbed and subsequently converted into the pharmacologically active norethisterone, through which it exerts its major biological effects. Within 2-4 hours after ingestion of lynestrenol peak plasma levels of norethisterone are reached. Lynestrenol and its metabolites are predominantly excreted in the urine, and to a less extent in the faeces.
Menstrual disorders: 5-10 mg daily as cyclic regimen. Contraception: 0.5 mg daily when used alone or 0.75-2.5 mg daily when used in combination with an oestrogen.
There are some indications, mainly obtained with other progestagen-containing preparations, that activated charcoal, barbiturates (primidone included), hydantoins and rifampicin may possibly decrease the effectiveness of Lynestrenol. Conversely, Lynestrenol may possibly increase the effectiveness of certain beta-adrenergic blockers and cyclosporin and possibly decrease the effectiveness of insulins.
vaginal bleeding,active venous thromboembolic disorders or severe arterial disease,hepatic impairment,progestogen-dependent tumours,porphyria. Pregnancy
GI disturbances,changes in appetite or weight,fluid retention,oedema,rashes,urticaria,mental depression,breast tenderness and pain,gynaecomastia,changes in libido,headache,migraine,altered menstrual cycle,irregular menstrual bleeding
There is positive evidence of human foetal risk,but the benefits from use in pregnant women may be acceptable despite the risk
Store in a cool & dry place, away from light. Keep the medicine out of the reach of children.
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