As Injection: As a local anaesthetic for use in infiltration blockade and intravenous regional analgesia. ? For the prevention and treatment of vetricular tachyarrhythmias. As topical: is indicated for surface anaesthesia of the male and female urethra, topical treatment of painful urethritis, anaesthetic lubrication for endotracheal intubation and for adequate analgesia in endoscopy
This is a sterile, non-pyrogenic aqueous solution that contains a local anaesthetic agent- Lidocaine Hydrochloride with Epinephrine. Lidocaine is a local anaesthetic of the amide type. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anaesthetic action. Lidocaine has a rapid onset of action and intermediate duration of action. The speed of onset and duration fo action are increased by the addition of vasconstrictor-epinephrine and absorption into circulation from the site of injection is reduced. The duration of action is approximately one and-a half to two hours with Epinephrine.
Adult : For healthy adults, the maximum individual should not exceed 4.5 mg/kg of body weight and in general it is recommended that the maximum total dose not exceed 300 mg. Recommended doses given in the following table serve only as a guide to the amount of anaesthetic required for most routine porcedures. Recommended Dosages Dose determined by number of dermatomes to be anesthetized (2-3 ml/dermatome).Antiarrhythmic treatment An intravenous dose of 1 mg/kg may be given over 2 minutes and repeated after 5 minutes but giving an infusion of 2-4 mg/min to produce a plasma level of 2-4 mg. To avoid a long delay in achieving a steady state, a loading dose of approximately 1 mg/kg-1 is usually given intravenously over 2 minutes at the outset.Topical :Urethral anaesthesia : ? Surface anaesthesia of the male adult urethra : For adequate analgesia in males 400 mg is required. ? Surface anaesthesia of the female adult urethra : Instil 100-200 mg in small portions to ll the whole urethra. In order to obtain adequate anaesthesia, several minutes should be allowed prior to perform in urological procedure. q Lubrication for endotracheal intubation : 100 mg applied on the surface of the tube just prior to insertion. Care should be taken to avoid introducing the product into the lumen of the tube. q Endoscopy: Instillation of 200-400 mg is recommended for adequate analgesia and a small amount should be applied on the instrument for lubrication. Debilitated, elderly patients and children should be given doses commensurate with their age and physical condition. Note: The applicator is sterilized for 5 minutes in boiling water, cooled and attached to the tube. The jelly is instilled slowly as required. The applicator should be detached after each use and keep the tube tightly closed.
It exhibits interaction with monoamine oxidase inhibitors, tricyclic antidepressants, phenothiazines, butyrophenones, vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type drugs
Known hypersensitivity to anaesthetics of the amide type.
In common with other local anaesthetics, adverse reactions to lidocaine are rare and are usually the result of excessively high blood concentrations due to inadvertent intravascular injection, excessive dosage, rapid absorption occasionally hypersensitivity, idiosyncracy or diminished tolerance on the part of the patient. In such circumstances systemic effects occur involving the central nervous system and/or depressant and may be characterized by nervousness, dizziness, blurred vision and tremors, followed by drowsiness, convulsions, unconsciousness and possibly respiratory arrest. cardiovascular reactions are hypotension, myocardial depression, bradycardia and possibly cardiac arrest. Allergic reactions are extremely rare. They may be characterized by cutaneous lesions, urticaria, oedema or anaphylactic reactions.
USE IN PREGNANCY AND LACTATION Although there is no evidence from animal studies of harm to the foetus, as with all drugs. It should not be given during early pregnancy unless the benefits are considered to outweigh the risks. Caution should be exercised when it is administered to a nursing woman
cute emergencies from local anesthetics are
generally related to high plasma levels encountered during therapeutic use of local anesthetics or to unintended subarachnoid injection of
local anesthetic solution
Store below 30°C in a dry place, away from light. Keep out of the reach of children.
Each mL contains
Lidocaine Hydrochloride USP (as anhydrous 20mg) &
Epinephrine 12.5mcg (as Epinephrine Bitartrate USP)
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