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Neuroradiology: Lumber myelography, thoraco-cervical myelography
Angiography: Cerebral angiography, selective coronary angiography, left ventriculography, aortography, angiocadiography, selective visceral arteriography, peripheral arteriography, digital subtraction angiography, venography, urography
Other diagnostic procedures: Contrast enhancement in CT scanning, arthrography, fistulography.
Iopamidol, an organic Iodine compound and used as a non-ionic water soluble radiographic contrast medium. Iopamidol blocks X-rays as they pass through the body, thereby allowing body structures not containing Iodine to be visualized. The degree of opacity produced by Iopamidol is directly proportional to the total amount of the iodinated contrast agent in the path of the X-rays. The visualization of body structures is dependent upon the distribution and elimination of Iopamidol.
Adult dosage:
Neurology: Lumber myelography: Iopamidol 370, 6-13 ml,
Thoraco-cervical myelography: Iopamidol 370, 6-13 ml.
Urography: Iopamidol 370, 40-80 ml IV up to 1.5 ml/kg in severe renal disease.
Children:
Usual Dose: 1-2.5 ml/kg
Other Diagnostic Procedure: Contrast enhancement in CT scanning: Iopamidol 370, 0.5-2.0 ml/kg
Iopamidol may interfere with thyroid function. Biguanide compete for excretion in the kidneys with contrast media and this could lead to reduction in kidney function. Patient taking Metformin or other Biguanides should therefore not take any doses of Metformin for 48 hours before or 48 hours after the X-ray examination.
There are no definite or absolute contraindications to the use of Amidol, with the possible exception of waldenstrom's macroglobulinemia, multiple myeloma and severe liver and kidney disease.
Common side effects are arrhythmias, arterial spasm, flushing, vasodilatation, angina, cardiopulmonary arrest; dizziness, confusion, paraesthesia, visual disturbances, seizure, paralysis, coma, temporary amnesia; inj site pain, pallor, periorbital and facial oedema; coughing, sneezing, rhinitis, asthma, apnoea, laryngeal oedema, chest tightness; watery itchy eyes, lachrymation, conjunctivitis; muscle spasm, involuntary leg movement; tremors, malaise; severe retching and choking, abdominal pain; urogenital pain, haematuria.
Iopamidol injection should be administered in pregnancy only if the procedure is considered essential by the physician.
Treatments of an overdose is directed toward the support of all vital functions and prompt institution of symptomatic therapy.
Store at 20-25° C
Iopamidol (300mg/ml, 370 mg/ml)