Other Antifungal preparations
Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin. It binds to keratin in human cells, then once it reaches the fungal site of action, it binds to fungal microtubes thus altering the fungal process of mitosis.
Adult : PO 0.5-1 g/day in single or divided doses. Treatment duration: 2-8 wk (hair and skin infections); up to 6 mth (fingernail infections); -12 mth (toenail infections). Should be taken with food. Take immediately after meals.
Patients on warfarin-type anticoagulant therapy may require dosage adjustment of the anticoagulant during and after Griseofulvin therapy. Concomitant use of barbiturates usually depresses Griseofulvin activity and may necessitate raising the dosage.
The concomitant administration of Griseofulvin has been reported to reduce the efficacy of oral contraceptives and to increase the incidence of breakthrough bleeding.
Hypersensitivity to griseofulvin. SLE and porphyria. Severe liver disease, hepatocellular failure. Pregnancy. Not intended for prophylaxis of fungal infections. Men should not father children w/in 6 mth of treatment. Lactation.
Skin rashes, urticaria, GI disturbances, dry mouth, taste alteration, headache, angioedema, leucopenia and other blood dyscrasias, proteinuria, oral candidiasis, peripheral neuropathy, photosensitisation, dizziness, confusion, depression, impaired coordination, insomnia, fatigue, exacerbation of SLE. Potentially Fatal: Severe skin reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme), hepatotoxicity.
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
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