Dextrose Is admInIstered as a parenteral nutrItIon solutIon In the treatment of carbohydrate depletIon and hypoglycaemIc coma. Because of Its hIgh dextrose content It Is used In the treatment of cerebral edema, shock, cIrculatory collapse, unconscIousness and to correct hyperkalaemIa wIth or wIthout InsulIn.
Intravenous fluid preparations, Parenteral Nutritional preparations
he volume and rate of infusion of dextrose solution will depend upon the requirements of the individual patient and the judgement of the physician. The maximum rate at which dextrose can be infused without producing glycosuria is 0.5 gm/kg/hr. The usual recommended flow rate for adult is 10-35 drops per minute infused intravenously. Intravenous- Hyperkalaemia: Adult: 25-50 g combined with 10 units of regular insulin, administered over 30-60 minutes; may repeat if necessary. Alternatively, 25 g combined with 5-10 units of regular insulin infused over 5 minutes; may repeat if necessary. Child and infants: 0.5-1 g/kg (using 25% or 50% solution) combined with regular insulin (1 unit for every 4-5 g dextrose given); infuse over 2 hr, may repeat if necessary. Intravenous- Hypoglycaemia: Adult: 10-25 g (40-100 ml of 25% solution or 20-50 ml of 50% solution). Doses may be repeated in severe cases. Child: ?6 mth: 0.25-0.5 g/kg/dose; >6 mth: 0.5-1 g/kg/dose. Doses may be repeated in severe cases. Max: 25 g/dose. Oral- Hypoglycaemia: Adult: 10-20 g as single dose; may repeat in 10 min if needed. Child: >2 yr: 10-20 g as single dose; may repeat in 10 min if It should not be administered by SC or IM route. Dextrose should be infused through the largest available peripheral vein.
There are no significant interactions reported with this medicine.
Concentrated dextrose solution is contraindicated in patients with Glucose-Galactose Malabsorption Syndrome and severe hydration. The infusion of hypertonic dextrose injections is contraindicated in patients having intracranial or intraspinal hemorrhage, in patients who are severely dehydrated, in patients who are anuric, and in patients in hepatic coma. Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products
Venous thrombosis, phlebitis, hypovolemia, hypervolemia, dehydration, oedema, fever, mental confusion, unconsciousness, hyperosmolar syndrome, hyperglycaemia, hypokalaemia, acidosis, hypophosphataemia, hypomagnesemia, polyuria, glycosuria, ketonuria, nausea, diarrhoea, polydipsia, vein irritation, tissue necrosis
Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Store in a dry place and away from light. Keep out of reach of children.
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