It is indicated for the treatment of nausea and vomiting during pregnancy.
Doxylamine Succinate is an antihistamine that blocks Histamine (H1) receptor. It can cross the blood brain barrier and has a high affinity for H1 receptors in the brain that blocks H1 receptors. It also decreases the action of histamine at the H1 receptor by inhibiting both vestibular system & Muscarinic receptor. It affects the vestibular system & decreases the stimulation of the vomiting center. Its muscarinic receptor inhibition may also play a role in antihistamine antiemetic activity. Pyridoxine Hydrochloride is a vitamin B6 analog. It is used to prevent nausea and vomiting due to its antiemetic properties.
Take two tablets daily at bedtime. If symptom persists, then take three tablets starting on day 3 (one tablet in the morning and two tablets at bedtime). If these three tablets can$#$#$#$t control symptoms adequately take maximun four tablets starting on day 4. (one tablet in the morning, one tablet mid-afternoon and two tablets at bedtime). Take on an empty stomach with a glass of water.
Use of Doxylamine Succinate & Pyridoxine Hydrochloride is contraindicated in women who are taking monoamine oxidase inhibitors (MAOIs), which prolong and intensify the adverse central nervous system effects (the anticholinergic effects) of antihistamines. Concurrent use of alcohol and other CNS depressants (such as hypnotic sedatives and tranquilizers) with Doxylamine Succinate & Pyridoxine Hydrochloride is not recommended.
This combination is contraindicated in women with known hypersensitivity to Doxylamine Succinate,other ethanolamine derivative antihistamines, Pyridoxine Hydrochloride, monoamine oxidase inhibitors (MAO) or any inactive ingredient in the formulation. Doxylamine Succinate & Pyridoxine Hydrochloride may cause somnolence due to the anticholin-ergic properties of Doxylamine Succinate. Women should avoid engaging in activities requiring complete mental alertness, such as driving or operating heavy machinery.Doxylamine Succinate & Pyridoxine Hydrochloride use is not recommended if a woman is concurrently using Central Nervous System (CNS) depressants including alcohol. The combination may result in severe drowsiness leading to falls or accidents. Use of Doxylamine Succinate & Pyridoxine Hydrochloride is contraindicated in women who are taking monoamine oxidase inhibitors (MAOIs), which prolong and intensify the anticholinergic (drying) e ects of antihistamines. Concurrent use of alcohol and other CNS depressants (such as hypnotic sedatives and tranquiliz-ers) with Doxylamine Succinate & Pyridoxine Hydrochloride is not recommended.
Side effects may include somnolence.
Pregnancy category A. So, Doxylamine Succinate & Pyridoxine Hydrochloride can be given to pregnant women safely.Women should not breastfeed while using Doxylamine Succinate & Pyridoxine Hydrochloride. The molecular weight of Doxylamine Succinate is low enough that passage into breast milk can be expected. Excitement, irritability and sedation have been reported in nursing infants presumably exposed to Doxylamine Succinate through breast milk. Infants with apnea or other respiratory syndromes may be particularly vulnerable to the sedative e ects of Doxylamine Succinate & Pyridoxine Hydrochloride resulting in worsening of their apnea or respiratory conditions
Doxylamine Succinate & Pyridoxine Hydrochloride is an extended-release or Delayed Release formulation; therefore, signs and symptoms of intoxication may not be apparent immediately. Signs and symptoms of overdose may include restlessness, dryness of mouth, dilated pupils, sleepiness, vertigo, mental confusion and tachycardia. At toxic doses, Doxylamine Succinate exhibits anticholinergic effects, including seizures, rhabdomyolysis, acute renal failure and death. If treatment is needed, it consists of gastric lavage or activated charcoal, whole bowel irrigation and symptomatic treatment.
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