Internal hemorrhoids, when used in combination with diosmin. The combination of hesperidin and diosmin seems to both significantly improve symptoms of hemorrhoids and also keep hemorrhoids, once healed, from coming back. Treating leg ulcers caused by poor circulation, when used in combination with diosmin.
Haemorrhoidal, phlebitis & varicose preparations
Diosmin and Hesperidin is a phlebotonic drug and a vascular protecting agent. It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus Diosmin and Hesperidin decreases venous capacitance, venous distensibility, and venous emptying time.
Diosmin and Hesperidin protects the microcirculation by fighting the microcirculation damaging process; It combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandin. Thus Diosmin and Hesperidin normalizes capillary permeability and strengthens capillary resistance.
Diosmin and Hesperidin acts on the lymphatic system, It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure.
450 mg of diosmin plus 50 mg of hesperidin twice daily
No evidence of drug incompatibility (drug interaction) has been reported in clinical trials.
Treatment was well accepted, and did not affect pregnancy, fetal development, birth weight, infant growth and feeding. CONCLUSION: In the short term, micronized diosmin 90% and hesperidin 10% is safe, acceptable, and effective in the treatment of hemorrhoids of pregnancy. When taken during lactation, the combination of hesperidin and diosmin does not seem to affect infant growth or feeding.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Each film coated tablet contains-
Diosmin micronised BP 450 mg
Hesperidin micronised INN 50 mg
Each DS film coated tablet contains-
Diosmin micronised BP 900 mg
Hesperidin micronised USP 100 mg
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