Dicloxacillin is indicated in Boils, Carbuncles, Cellulitis, Endocarditis, Folliculitis, Impetigo, Mastitis, Osteomyelitis, Otitis externa, Pneumonia, Septic Arthritis, Staphylococcal skin infections, Streptococcus Septicaemia, Surgical Prophylaxis, Throat infections.
Penicillinase-resistant penicillins
Adult: 125-250 mg 6 hourly. Doses may be doubled in severe infections. Child: <40 kg: 12.5-25 mg/kg 6 hourly. Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals.
Hypersensitivity to dicloxacillin and other penicillins. Patient with history of allergy esp ?-lactam allergy, asthma. Pregnancy and lactation.
Hypersensitivity reactions (e.g. urticaria, fever, joint pains, rashes, angioedema, serum sickness-like reactions), nausea, vomiting, diarrhoea, stomatitis, black/hairy tongue, neurotoxic reactions, renal tubular damage, interstitial nephritis, eosinophilia, haemolytic anaemia, agranulocytosis, neutropenia, leucopenia, granulocytopenia, bone marrow depression, hepatotoxicity, cholestatic hepatitis.
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
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