This product should not usually be used for an ongoing cough from smoking or long-term breathing problems (e.g., chronic bronchitis, emphysema) unless directed by your doctor. This product contains dextromethorphan. It is a cough suppressant that works by decreasing the feeling of needing to cough.
Dextromethorphan Hydrobromide is a cough suppressant which has a central action on the cough centre in the medulla. Although structurally related to morphine, it has no analgesic properties and in general it has little sedative activity. Addiction has not been observed after the administration of rather large doses for prolonged period. It is rapidly absorbed from the GI tract and exerts its effects in 15-30 minutes after oral administration. The duration of action is approximately 3-6 hours with conventional dosage form. Dextromethorphan hydrobromide is extensively metabolised in the liver and excreted in the urine as unchanged Dextromethorphan and demethylated metabolites including Dextrophan which has some cough suppressant activity. Urinary excretion of parent and metabolites accounts for up to 50% of the ingested dose over 24 hours. About 8% of the dose is excreted unchanged in the urine over the first 6 hours.
Usual Adult Dose for Cough Immediate-release: 10 to 20 mg orally every 4 hours or 30 mg orally ever 6 to 8 hours Extended-release: 60 mg orally every 12 hours Maximum dose: 120 mg in 24 hours Use: For the temporary relief of cough due to minor throat and bronchial irritation as may occur with the common cold or inhaled irritants. Usual Pediatric Dose for Cough Under 4 years: Not recommended 4 to 6 years: Immediate-release: 2.5 to 5 mg orally every 4 hours or 7.5 mg orally every 6 to 8 hours Extended-release: 15 mg orally every 12 hours Maximum dose: 30 mg in 24 hours 6 to 12 years: Immediate-release: 5 to 10 mg orally every 4 hours or 15 mg orally every 6 to 8 hours Extended-release: 30 mg every 12 hours Maximum dose: 60 mg in 24 hours 12 years or older: Immediate-release: 10 to 20 mg orally every 4 hours or 30 mg orally ever 6 to 8 hours Extended-release: 60 mg orally every 12 hours Maximum dose: 120 mg in 24 hours
Two fatal interactions have been reported in patients taking therapeutic doses of phenelzine and dextromethorphan.
Patients at risk of developing resp failure. During an acute attack. Patients receiving MAOI or for 2 wk after discontinuing them. Persistent or chronic cough. 3rd trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma. Moderate to severe renal impairment; liver disease.
Dizziness. Gl disturbances.
Dextromethorphan Is Safe in Pregnancy. The cough suppressant dextromethorphan has long been used during breastfeeding and is considered safe. If you need an antihistamine, also used to treat allergies, they are generally considered safe.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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