This medication is used to treat acne. It helps decrease the number and severity of acne pimples and helps pimples that do develop to heal more quickly. Dapsone is an antibiotic. It is not known how dapsone works to treat acne.
Dapsone has both anti-infammatory and antimicrobial properties. A combination of these activities may account for its efcacy in acne. Anti-infammatory efects include inhibition of neutrophil myeloperoxidase and eosinophil peroxidase activity, suppression of hypochlorous acid production, scavenging of reactive oxygen species, suppression of neutrophil activity, and inhibition of chemoattractant-induced signal transduction. Antimicrobial activity, similar to that of sulfones and sulfonamides, is by inhibition of bacterial dihydropteroate synthase in the folic acid metabolic pathway. This mechanism is efective against microorganisms synthesizing their own folic acid. In vitro susceptibility testing has demonstrated some activity for Dapsone against Propionibacterium species, including Propionibacterium acnes (P. acnes).
\"Apply once daily . Apply approximately a pea-sized amount of Dapsone Gel, 7.5%, in a thin layer to the entire face. A thin layer can also be applied to other affected areas. If there is no improvement after 12 weeks, treatment with Dapsone Gel, 7.5% should be reassessed . For topical use only. Not for oral, ophthalmic, or intravaginal use.\"
Trimethoprim/ sulfamethoxazole (TMP/ SMX) increases the systemic level of Dapsone and its metabolites. Topical benzoyl peroxide used at the same time as Dapsone may result in temporary local yellow or orange skin discoloration.
Most common (incidence ≥ 0.9%) adverse reactions are application site dryness and pruritus
There are no available data on Dapsone Gel, 7.5%, use in pregnant women to inform a drug-associated risk for adverse developmental outcomes.
Store at or below 30°C temperature. Keep away from light and wet place. Keep out of reach of children.
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