Allergic and vasomotor rhinitis, conjunctivitis, urticaria, angioedema, reactions to blood. Adjunct in anaphylaxis. Cold urticaria.
Cyproheptadine appears to exert its antihistamine and antiserotonin effects by competing with free histamine and serotonin for binding at their respective receptors.9 Antagonism of serotonin on the appetite center of the hypothalamus may account for cyproheptadine's ability to stimulate the appetite.
ORAL Allergic conditions: Adult: As HCI: 4 mg tid adjusted as necessary. Usual dose range: 12-16 mg daily in 3-4 divided doses. Up to 32 mg daily may be used in some cases. Child: As HCI: 2-6 yr: 2 mg tid (max: 12 mg daily); 7-14 yr: 4 mg bidt id (max: 16mg daily).
1,2-Benzodiazepine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with 1,2-Benzodiazepine.
Acebutolol The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Acebutolol.
Acenocoumarol The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Acenocoumarol.
Acetazolamide The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Acetazolamide.
Acetophenazine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Acetophenazine.
Narrow-angle glaucoma: acute asthmatic attack: bladder neck obstruction; stenosing peptic ulcer; GIT obstruction; MAOIs therapy; hypersensitivity; neonates, lactation. Elderly; epilepsy; tasks requiring mental alertness; symptomatic prostate hypertrophy; epilepsy; alcoholism; pregnancy.
Slight to moderate drowsiness, fatigue; dry mouth, Gl upsets. nausea; appetite increase, wt gain & impaired alertness.
There are no controlled data in human pregnancy. Cyproheptadine is only recommended for use during pregnancy when benefit outweighs risk. There are no data on the excretion of cyproheptadine into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Overdosage with cyproheptadine is likely to result in significant sedation - although paradoxical stimulation has been noted in pediatric patients - and anticholinergic adverse effects such as dry mouth and flushing.8 Most patients appear to recover without incident, as a review of cyproheptadine overdose cases in Hong Kong found the majority of patients had no or mild symptoms following intentional overdose.
In the event of overdosage with cyproheptadine, prescribing information recommends the induction of vomiting (if it has not occurred spontaneously) using syrup of ipecac.8 Gastric lavage and activated charcoal may also be considered. Vasopressors may be used to treat hypotension and intravenous physostigmine salicylate may be considered for the treatment of significant CNS symptoms depending on the clinical picture.
Store in a cool (Below 25°C temperature) and dry place protected from light. Keep out of the reach of children.
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