Coenzyme Q10 is likely effective in alternative medicine as an aid in treating coenzyme Q-10 deficiency, or reducing the symptoms of mitochondrial disorders (conditions that affect energy-production in the cells of the body). Coenzyme Q10 is also possibly effective in preventing migraine headaches, lowering blood pressure, preventing a second heart attack, or slowing the progression of early Parkinson's disease. This medicine is also possibly effective in improving symptoms in people with congestive heart failure, nerve problems caused by diabetes, Huntington's disease, muscular dystrophy, or macular degeneration (age-related vision loss). Coenzyme Q10 has also been used to treat Alzheimer's disease, high cholesterol, or amyotrophic lateral sclerosis (Lou Gehrig's disease). However, research has shown that this medicine may not be effective in treating these conditions.
The USP refers to Coenzyme Q10 as Ubidecarenone which is a fat-soluble vitamin like substance. It is presented in every cell of the body and acts as a vital intermediate of the electron transport system in the mitochondrial membrane for cellular respiration and ATP production. The highest requirement of Ubidecarenone is found in the cells and tissues that are of metabolically active such as- heart, immune system, skeleton muscle, gingiva and most susceptible to Ubidecarenone deficiency. The Production of Ubidecarenone slows down with advancing age and thus contribute in manifestation of aging.
As Ubidecarenone is a lipophilic substance, it is absorbed less on an empty stomach and absorbed in greater amount when taken with food of high lipid content. Thus, after oral administration, Ubidecarenone is absorbed from the small intestine into the lymphatics system and then taken up by the liver where it is incorporated into lipoproteins and released into the blood circulation and at that time concentrated in the tissues.
Ubidecarenone is distributed to the various tissues of the body and is able to enter into the brain. The concentration varies from tissue to tissue and those with high rates of metabolic activity and high energy demands such as heart, muscle, liver, kidney and brain contain relatively high concentration of Ubidecarenone. Ubidecarenone is metabolized in all tissues in the body. Approximately 60% of an oral dose of Ubidecarenone is excreted in the feces. The main elimination of Ubidecarenone occurs with bile.
Tablets: 25 mg, 50 mg Capsules: 10 mg, 30 mg, 60 mg
Statins: The statin drugs reduce endogenous synthesis of Ubidecarenone in the body. Thus, Ubidecarenone supplement may increase Ubidecarenone levels without adversely affecting statin drug's efficacy.
Warfarin: May reduce the effectiveness of warfarin.
Beta-blockers: Beta blockers (particularly propanolol) have been reported to inhibit some Ubidecarenone dependent enzymes,
Antidiabetic medications: May improve glycemic control in some type II diabetics. If this occurred, antidiabetic medications may need appropriate dose adjustment.
Doxorubicin: May help ameliorate the cardiotoxicity of doxorubicin।
upset stomach, nausea, vomiting, loss of appetite; diarrhea; skin rash; or low blood pressure.
Keep in a dry place away from light and heat. Keep out of the reach of children.
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