This combination is indicated for H. pylori infection, Peptic ulcer disease.
Clarithromycin 500 mg, metronidazole 500 mg & lansoprazole 30 mg twice daily for 7-14 days or as per the physicians advice.
Contraindicated in patients with known severe hypersensitivity to any component. Clarithromycin is contraindicated in patients with a history of cholestatic jaundice/ hepatic dysfunction associated with prior use of clarithromycin. Clarithromycin should not be given to patients with history of QT prolongation or ventricular cardiac arrhythmia, including torsades de pointes. Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on penicillin therapy, including amoxicillin. Although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillins. These reactions are more likely to occur in individuals with a history of penicillin hypersensitivity and/or a history of sensitivity to multiple allergens.
Adverse reactions which were reported as possibly or probably related to treatment (<3%) in clinical trials when all three components of this therapy were given concomitantly are listed below and divided by body systems. Common side effects are nausea, vomiting, diarrhoea, dark stool, glossitis, oral moniliasis, stomatitis, tongue discoloration, myalgia, Nervous System: confusion, headache, dizziness, skin reactions, vaginitis, vaginal moniliasis.
Pregnancy Category-Not Classified. FDA has not yet classified the drug into a specified pregnancy category.
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