Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing.
Alkylamine Derivative; Antihistamine
Chlorpheniramine Maleate is an alkylamine antihistamine. It is one of the most potent histamine H1-receptor blocking agents which is used as a potent antihistamine. This generally causes less sedation than promethazine. Chlorpheniramine Maleate exerts its effects by blocking H1-receptor competitively.
ORAL Allergic conditions: Adult: 4 mg every 4-6 hr. Max: 24 mg daily. Child: 1-2 yr: 1 mg bid, 2-5 yr: 1 mg every 4-6 hr, 6-12 yr: 2 mg every 4-6 hr. Max: 6 mg daily (1-5 yr); 12mg daily (6-12 yr). Parenteral Adjunct in the emergency treatment of anaphylactic shock: Adult: 10-20 mg IM, sc, or slow IV inj over 1 min. Max dose: 40 mg daily. child: 87.5 mcg/kg SC 4 times daily
Chlorphenamine maleate has been reported to be incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium, and meglumine adipiodone.
Hypersensitivity, neonates. Elderly, pylon duodenal obstruction, angleclosure glaucoma, urinary retention, prostatic hyperplasia, epilepsy, renal & hepatic impairment. May affect performance of skilled tasks. BPH, bladder neck obstruction, hypertension. Pregnancy, lactation.
CNS depression, sedation, drowsiness, lassitude, dizziness. GI upsets, anorexia, or increased appetite, epigastric pain, blurring of vision, dysuria, dryness of mouth, tightness in chest, hypotension, muscular weakness, tinnitus, euphoria, headache, paradoxical CNS stimulation. CV collapse & resp failure.
There are no controlled data in human pregnancy. Chlorpheniramine is only recommended for use during pregnancy when benefit outweighs risk. There are no data on the excretion of chlorpheniramine into human milk. However, because other antihistamines are excreted into human milk in low concentrations. Caution be used when administering chlorpheniramine to nursing women.
CNS depression (including sedation, apnea, CV collapse), CNS stimulation (including insomnia, hallucination, tremors, convulsions), tinnitus, blurred vision, dizziness, ataxia, hypotension. Stimulation and atropine-like signs and symptoms (including dry mouth, fixed dilated pupils, flushing, hyperthermia, Gl symptoms) are more likely in children.
Store in a cool (Below 25°C temperature) and dry place protected from light. Keep out of the reach of children.
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