Lower Respiratory Tract Infections,Acute Otitis Media,Skin & Skin Structure Infections,Urinary Tract Infections,Intra-Abdominal Infections,Meningitis,Bone and Joint Infections,Septicemia,Uncomplicated Gonorrhea,Pelvic Inflammatory Diseases,Surgical Prophylaxis
Third generation Cephalosporins
Adults : The usual adult daily dose is 1 to 2 g given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. The total daily dose should not exceed 4 g. Severe infections: 2-4 g daily,normally as a single dose every 24 hours. Uncomplicated gonorrhoea: A single dose of 250 mg intramuscularly should be administered. Surgical prophylaxis: A single dose of 1 g administered intravenously ? to 2 hours before surgery is recommended. Neonates: By intravenous infusion over 60 minutes,20?50 mg/kg daily (max. 50 mg/kg daily). Children: 20-50 mg/kg daily as a single dose,maximum upto 80 mg/kg as a single dose in severe infections; doses over 50 mg/kg should be given through intravenous infusion only. Skin and skin structure infections : The recommended total daily dose is 50 to 75 mg/kg given once a day (or in equally divided doses twice a day). The total daily dose should not exceed 2 g. Acute bacterial otitis media: A single intramuscular dose of 50 mg/ kg is recommended. Serious miscellaneous infections other than meningitis: The recommended total daily dose is 50 to 75 mg/kg,given in divided doses every 12 hours. The total daily dose should not exceed 2 g. Meningitis : It is recommended that,the initial therapeutic dose is 100 mg/kg (not to exceed 4 g). Thereafter,a total daily dose of 100 mg/kg/day (not to exceed 4 g daily) is recommended. The daily dose may be administered once a day (or in equally divided doses every 12 hours). The usual duration of therapy is 7 to 14 days. Use in the elderly: The recommended dosages for adults do not require modification in the case of elderly patients provided that renal and hepatic functions are satisfactory. Renal and hepatic impairment: In patients with impaired renal function,there is no need to reduce the dosage of Ceftriaxone provided liver function is intact. Only in cases of pre-terminal renal failure (creatinine clearance < 10 ml per minute) should the daily dosage be limited to 2 g or less. In patients with liver damage there is no need for the dosage to be reduced provided renal function is intact. Duration of Therapy: Generally,Trizon (Ceftriaxone) therapy should be continued for at least 2 days after the signs and symptoms of infection have disappeared. The usual duration of therapy is 4 to 14 days. In complicated infections,longer therapy may be required.
Ceftriaxone should not be given in patients with a history of hypersensitivity to cephalosporin antibiotics. It is contra-indicated in premature infants and neonates with jaundice, hypoalbuminaemia,acidosis or impaired bilirubin binding; concomitant treatment with calcium in neonates & children.Care is required when administering Ceftriaxone to patients who have previously shown hypersensitivity to penicillins or other non-cephalosporin beta-lactam antibiotics.
Care is required when administering Ceftriaxone to patients who have previously shown hypersensitivity to penicillins or other non-cephalosporin beta-lactam antibiotics.
Pregnancy Category B. Ceftriaxone should be used during pregnancy only if clearly needed. Low concentrations of Ceftriaxone are excreted in human milk; caution should be exercised when Ceftriaxone is administered to a nursing mother.
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