Acute or chronic bronchitis, bacterial pneumonia, infected bronchiectasis, lung abscess & post-operative chest infections, acute & chronic pyelonephritis, cystitis & asymptomatic bacteriuria, cellulitis, peritonitis & wound infections, osteomyelitis, septic arthritis, pelvic inflammatory disease, gonorrhoea, meningitis & other sensitive infections suitable for parenteral antibiotic therapy.
3rd Generation Cephalosporin Antimicrobial
Cefotaxime binds to 1 or more of the penicillin binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefotaxime is a broad spectrum bactericidal 3rd generation parenteral cephalosporin antibiotic. Cefotaxime is exceptionally active against gram-negative organisms sensitive or resistant to first or second generation cephalosporins. It is similar to other cephalosporins in activity against gram-positive bacteria.
1gm every 12 hourly. In severe infections dosage may be increased up to 12 gm daily given in 3 or 4 divided doses. Children : 100- 150 mg/kg/day in 2 to 4 divided doses. In very severe infections doses up to 200 mg/kg/day may be required. Neonates : 50 mg/kg/day in 2-4 divided doses. In severe infections 150-200 mg/kg/ day in divided doses.
Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.
Hypersensitivity, in renal insufficiency.
Mild & transient candidiasis, rashes, fever, transient rises in liver transaminase and/or alkaline phosphatase & diarrhoea. pseudomembranous colitis, changes in renal function, skin rashes, drug fever & very rarely anaphylaxis. Administration of high doses of cephalosporins particularly in patients with renal insufficiency may result in encephalopathy.
Pregnancy Category B. Cefotaxime is excreted in the milk. Caution should be exercised when Cefotaxime is administered to a nursing women.
Store below 25°C, protected from light and moisture. Use reconstituted solution immediately. Reconstituted solution is stable for up to 24 h if stored between 2° to 8°C.
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