Betamethasone Dipropionate is indicated for the relief of the inflammatory & pruritic manifestations of resistant or severe corticosteroid responsive dermatoses. These include- atopic eczema, nummular eczema, contact dermatitis, neurodermatitis, anogenital & senile pruritus, lichen planus & psoriasis.
Betamethasone Dipropionate is a topical corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive properties. Betamethasone Dipropionate induces peptides called lipocortins. Lipocortins antagonize phospholipase A2, an enzyme that causes the breakdown of leukocyte lysosomal membranes to release arachidonic acid. This action decreases the subsequent formation and release of endogenous inflammatory mediators including prostaglandins, kinins, histamine.
Pharmacokinetics: Betamethasone Dipropionate can be absorbed from normal intact skin. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver.lt excreted by the kidneys.
Apply a thin film once or twice daily to cover completely the affected area. Patients with chronic psoriasis who have achieved at least a marked improvement in their psoriatic lesion (i.e., approximately 80% improvement) with Betamethasone Dipropionate may be maintained in remission with a pulse dosing regimen consisting of three consecutive applications of up to 3.5 g each of Betamethasone Dipropionate Cream & Ointment, twelve hours apart (e.g., morning, evening, following morning) to the previously affected areas once each week. For this purpose, Betamethasone Dipropionate cream & ointment should be applied to the lesion sites previously affected & treated. Patients on this pulse dose regimen who relapse should be reverted back to the conventional dosing regimen. Not recommended under one year of age, or under the nappy, or airtight dressing of an infant older than one year.
There is no evidence of any kind of interaction.
Hypersensitivity to Betamethasone Dipropionate, other corticosteroids. Like other topical corticosteroids, Betamethasone Dipropionate is contraindicated in viral infections of the skin, such as vaccinia, varicella & Herpes simplex, also tuberculosis, acne rosacea, fungal skin infections, perioral dermatitis & ulcerative conditions.
The most frequent side effects reported with Betamethasone Dipropionate are mild to moderate transient burning/stinging, dry skin, pruritus, irritation & folliculitis. Rarely reported adverse effects include tingling, prickly skin/ tightening or cracking of skin, warm feeling, laminar scaling & perilesional scaling, follicular rash, skin atrophy, erythema, urticaria, vesiculation, telangiectasia, acneiform papules & hyperaesthesia.
This medicine should not be used during pregnancy & during lactation unless considered essential by your doctor.
Acute overdose with the ointment is unlikely and would not be expected to lead to a life-threatening situation. The ointment should not be used for longer than the prescribed time period.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Each gram cream contains Bethamethasone 0.5 mg as Betamethasone Dipropionate.
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