Seasonal allergic rhinitis in patients 12 years of age and older
Nasal Steroid Preparations
Azelastine Hydrochloride exhibits histamine H1-receptor antagonist activity in isolated tissues. The major metabolite, desmethylazelastine, also possesses H1-receptor antagonist activity. Fluticasone Propionate is a synthetic trifluorinated corticosteroid with anti-inflammatory activity. The precise mechanism through which Fluticasone Propionate affects allergic rhinitis symptoms is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes etc.) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation.
For adults and adolescents (12 years and older): One spray per nostril twice daily.
Avoid driving or operating machinery. Avoid concurrent use of alcohol or other central nervous system (CNS) depressants with Flonasin. Hypercorticism and adrenal suppression with very high dosages or at the regular dosage in susceptible individuals. If such changes occur,discontinue the spray slowly.
Dysgeusia, epistaxis, and headache.
Pregnancy category C. It should be used in pregnant women only if the potential benefit to the mother justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing woman.
There have been no reported over dosages with Azelastine Hydrochloride. Acute Azelastine Hydrochloride overdosage by adults with this dosage form is unlikely to result in clinically significant adverse events, other than increased somnolence. Chronic Fluticasone Propionate overdosage may result in symptoms of hypercorticism.
Store below 25°C. Protected from light. Do not store in the refrigerator. Keep out of the reach of children.
Each metered spray delivers Azelastine Hydrochloride BP 137 mcg and Fluticasone Propionate BP 50 mcg.
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